Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect
Sign Up to like & getrecommendations! Published in 2017 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2016.09.006
Abstract: Current understanding on the mechanisms of brain injury and neurodegeneration highlights an appreciation of multicellular interactions within the neurovascular unit (NVU), which include the evolution of blood-brain barrier (BBB) damage, neuronal cell death or degeneration,… read more here.
Keywords: stroke neurodegenerative; unit ischemic; neurodegenerative diseases; dysfunction neurovascular ... See more keywords
Integrating in vitro disease models of the neurovascular unit into discovery and development of neurotherapeutics.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in biomedical engineering"
DOI: 10.1016/j.cobme.2021.100341
Abstract: The blood-brain barrier (BBB) regulates the transport of small molecules, proteins, and cells between the bloodstream and the central nervous system (CNS). Brain microvascular endothelial cells work with other resident brain cell types, including pericytes,… read more here.
Keywords: discovery development; disease; discovery; brain ... See more keywords
Application and advantages of zebrafish model in the study of neurovascular unit.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174483
Abstract: The concept of "Neurovascular Unit" (NVU) was put forward, so that the research goal of Central Nervous System (CNS) diseases gradually transitioned from a single neuron to the structural and functional integrity of the NVU.… read more here.
Keywords: model; neurovascular unit; cns diseases; zebrafish model ... See more keywords
Therapeutic strategy against ischemic stroke with the concept of neurovascular unit
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.03.022
Abstract: ABSTRACT Stroke is one of the leading causes of death and disability globally. Although thrombolytic therapy by t‐PA and mechanical thrombectomy have improved outcomes of ischemic stroke patients, both of these approaches are applicable to… read more here.
Keywords: ischemic stroke; concept neurovascular; stroke concept; neurovascular unit ... See more keywords
Catalytic Bioswitch of Platinum Nanozymes: Mechanistic Insights of Reactive Oxygen Species Scavenging in the Neurovascular Unit
Sign Up to like & getrecommendations! Published in 2023 at "Nano Letters"
DOI: 10.1021/acs.nanolett.3c01479
Abstract: Oxidative stress is known to be the cause of several neurovascular diseases, including neurodegenerative disorders, since the increase of reactive oxygen species (ROS) levels can lead to cellular damage, blood–brain barrier leaking, and inflammatory pathways.… read more here.
Keywords: reactive oxygen; platinum; neurovascular unit; oxygen species ... See more keywords
An engineered neurovascular unit for modeling neuroinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Biofabrication"
DOI: 10.1088/1758-5090/abf741
Abstract: The neurovascular unit (NVU) comprises multiple types of brain cells, including brain endothelial cells, astrocytes, pericytes, neurons, microglia, and oligodendrocytes. Each cell type contributes to the maintenance of the molecular transport barrier and brain tissue… read more here.
Keywords: neuroinflammation; neurovascular unit; nvu composing; brain ... See more keywords
Autophagy in the retinal neurovascular unit: New perspectives into diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.13373
Abstract: Diabetic retinopathy (DR) is one of the most prevalent retinal disorders worldwide, and it is a major cause of vision impairment in individuals of productive age. Research has demonstrated the significance of autophagy in DR,… read more here.
Keywords: unit new; neurovascular unit; unit; autophagy retinal ... See more keywords
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three‐dimensional matrix
Sign Up to like & getrecommendations! Published in 2021 at "Brain Pathology"
DOI: 10.1111/bpa.12940
Abstract: Neurovascular dysfunction is a primary or secondary cause in the pathogenesis of several cerebrovascular and neurodegenerative disorders, including stroke. Therefore, the overall protection of the neurovascular unit (NVU) is a promising therapeutic strategy for various… read more here.
Keywords: three dimensional; primary neural; neurovascular unit; pathology ... See more keywords
AT1‐R is involved in the development of long‐lasting, region‐dependent and oxidative stress‐independent astrocyte morphological alterations induced by Ketamine
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14756
Abstract: Astrocytes play an essential role in the genesis, maturation and regulation of the neurovascular unit. Multiple evidence support that astrocyte reactivity has a close relationship to neurovascular unit dysfunction, oxidative stress and inflammation, providing a… read more here.
Keywords: neurovascular unit; lasting region; stress; long lasting ... See more keywords
Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17210
Abstract: The term neurovascular unit (NVU) describes the structural and functional liaison between specialized brain endothelium, glial and mural cells, and neurons. Within the NVU, the blood-brain barrier (BBB) is the microvascular structure regulating neuronal physiology,… read more here.
Keywords: dysfunction; neurovascular unit; seizures epilepsy; brain ... See more keywords
Targetability of the neurovascular unit in inflammatory diseases of the central nervous system
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13121
Abstract: The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs… read more here.
Keywords: bbb; central nervous; nervous system; neurovascular unit ... See more keywords