Sequence analysis‐based characterization and identification of neurovirulence‐associated variants of 36 EV71 strains from China
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DOI: 10.1002/jmv.25081
Abstract: Enterovirus 71 (EV71) is the main pathogen of hand‐foot‐mouth disease (HFMD) and causes several neurological complications. As new strains of EV71 are constantly discovered, it is important to understand the genomic characteristics of the viruses… read more here.
Keywords: amino acid; neurovirulence; analysis; sequence analysis ... See more keywords
Interferon regulated gene (IRG) expression-signature in a mouse model of chikungunya virus neurovirulence
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DOI: 10.1007/s13365-017-0583-3
Abstract: Interferon regulated genes (IRGs) are critical in controlling virus infections. Here, we analyzed the expression profile of IRGs in the brain tissue in a mouse model of chikungunya virus (CHIKV) neurovirulence. Neurovirulence is one of… read more here.
Keywords: interferon regulated; neurovirulence; expression; mouse model ... See more keywords
Neurovirulence of Avian Influenza Virus Is Dependent on the Interaction of Viral NP Protein with FMRP in the Murine Brain
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DOI: 10.1128/jvi.01272-20
Abstract: Infection of the CNS is a serious complication of human cases of AIV infection. The viral and host factors associated with neurovirulence of AIV infection are not well understood. ABSTRACT Avian influenza viruses (AIVs) are… read more here.
Keywords: avian influenza; virus; neurovirulence; protein ... See more keywords
RNA Structure in the 5′ Untranslated Region of Enterovirus D68 Strains with Differing Neurovirulence Phenotypes
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DOI: 10.3390/v15020295
Abstract: Enterovirus-D68 (EV-D68) is a positive-sense single-stranded RNA virus within the family Picornaviridae. EV-D68 was initially considered a respiratory virus that primarily affected children. However, in 2014, EV-D68 outbreaks occurred causing the expected increase in respiratory… read more here.
Keywords: structure; d68; neurovirulence; d68 strains ... See more keywords
Live Viral Vaccine Neurovirulence Screening: Current and Future Models
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DOI: 10.3390/vaccines9070710
Abstract: Live viral vaccines are one of the most successful methods for controlling viral infections but require strong evidence to indicate that they are properly attenuated. Screening for residual neurovirulence is an important aspect for live… read more here.
Keywords: neurovirulence screening; viral vaccine; screening current; neurovirulence ... See more keywords