Mechanics of neurulation: From classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube
Sign Up to like & getrecommendations! Published in 2017 at "Birth Defects Research"
DOI: 10.1002/bdra.23557
Abstract: Neural tube defects arise from mechanical failures in the process of neurulation. At the most fundamental level, formation of the neural tube relies on coordinated, complex tissue movements that mechanically transform the flat neural epithelium… read more here.
Keywords: tissue movements; neurulation; tube; neural tube ... See more keywords
Sox2-dependent regulation of stem cell-like precursors during secondary neurulation
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.473
Abstract: In vertebrates, the neurulation proceeds by two distinct processes, primary neurulation (PN) and secondary neurulation (SN), which construct the neural tube in the anterior and posterior regions of the body, respectively. We have been studying… read more here.
Keywords: neurulation; neural tube; stem cell; sox2 ... See more keywords
Neural-fated self-renewing cells regulated by Sox2 during secondary neurulation in chicken tail bud.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.02.007
Abstract: In amniotes, unlike primary neurulation in the anterior body, secondary neurulation (SN) proceeds along with axial elongation by the mesenchymal-to-epithelial transition of SN precursors in the tail bud. It has been under debate whether the… read more here.
Keywords: neurulation; self renewing; uni fated; tail bud ... See more keywords
Modeling neurulation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Methods"
DOI: 10.1038/s41592-019-0680-8
Abstract: As an early stage of human development, neurulation sees the formation of the main ectodermal lineages, including neural progenitors, neural crest, sensory placodes and epidermis. Ectodermal lineages are involved in a number of genetic diseases,… read more here.
Keywords: modeling neurulation; neurulation; development;
Limited Dorsal Myeloschisis: Reconsideration of its Embryological Origin.
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgery"
DOI: 10.1093/neuros/nyy632
Abstract: BACKGROUND Limited dorsal myeloschisis (LDM) is postulated to be a result of incomplete dysjunction in primary neurulation. However, clinical experience of LDM located below the first-second sacral (S1-S2) vertebral level, which is formed from secondary… read more here.
Keywords: neurulation; limited dorsal; ldm; level ... See more keywords
Understanding the Role of ATP Release through Connexins Hemichannels during Neurulation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032159
Abstract: Neurulation is a crucial process in the formation of the central nervous system (CNS), which begins with the folding and fusion of the neural plate, leading to the generation of the neural tube and subsequent… read more here.
Keywords: atp release; hcs cxs; neurulation; release ... See more keywords
Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.73075
Abstract: The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coactivator Yes-associated protein 1 (YAP). Hippo-YAP signaling has been shown to… read more here.
Keywords: role; ectodermal specification; neurulation; huntington disease ... See more keywords
Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.74464
Abstract: The epiblast of vertebrate embryos is comprised of neural and non-neural ectoderm, with the border territory at their intersection harboring neural crest and cranial placode progenitors. Here, we a generate single-cell atlas of the developing… read more here.
Keywords: neurulation; neural crest; border; neural plate ... See more keywords