Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0784-z
Abstract: Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral sphingomyelinase 2 (nSMase2) were elucidated in this study. nSMase2 mRNA expression was greatest in… read more here.
Keywords: lipid raft; striatum; neutral sphingomyelinase; inhibition ... See more keywords
Interaction of Synaptosomal-Associated Protein 25 with Neutral Sphingomyelinase 2: Functional Impact on the Sphingomyelin Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.08.015
Abstract: Neurotransmitter release is mediated by ceramide, which is generated by sphingomyelin hydrolysis. In the present study, we examined whether synaptosomal-associated protein 25 (SNAP-25) is involved in ceramide production and exocytosis. Neutral sphingomyelinase 2 (nSMase2) was… read more here.
Keywords: associated protein; synaptosomal associated; neutral sphingomyelinase; release ... See more keywords
Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869
Sign Up to like & getrecommendations! Published in 2018 at "Cell Discovery"
DOI: 10.1038/s41421-018-0017-2
Abstract: Zika virus (ZIKV) is a neurotrophic flavivirus that is capable of infecting humans, leading to brain abnormalities during fetal development. The ZIKV infectivity in neural target cells remains poorly understood. Here, we found that ZIKV… read more here.
Keywords: inhibitor; fetal astrocytes; human fetal; neutral sphingomyelinase ... See more keywords
Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac106
Abstract: Alcohol use, abuse, and addiction, and resulting health hazards are highly sex-dependent with unknown mechanisms. Previously, strong links between the SMPD3 gene and its coded protein neutral sphingomyelinase 2 (NSM) and alcohol abuse, emotional behavior,… read more here.
Keywords: behavior; drinking emotional; neutral sphingomyelinase; alcohol ... See more keywords
Neutral sphingomyelinase‐2 and cardiometabolic diseases
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DOI: 10.1111/obr.13248
Abstract: Sphingolipids, in particular ceramides, play vital role in pathophysiological processes linked to metabolic syndrome, with implications in the development of insulin resistance, pancreatic ß‐cell dysfunction, type 2 diabetes, atherosclerosis, inflammation, nonalcoholic steatohepatitis, and cancer. Ceramides… read more here.
Keywords: biochemistry; sphingomyelinase cardiometabolic; cardiometabolic diseases; neutral sphingomyelinase ... See more keywords
Elevated Estrogen Induces Senescence in Male Endothelial Cells Via Neutral Sphingomyelinase-Mediated Ceramide Formation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5723931
Abstract: Prevalence of cardiovascular disease is higher among trans-females undergoing estrogen therapy compared to cis-females and males. Our previous work has shown that chronic exposure to elevated estrogen induces microvascular endothelial dysfunction in arterioles collected from… read more here.
Keywords: elevated estrogen; estrogen; physiology; estrogen induces ... See more keywords
Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson's Disease and in Embryonic Hippocampal Cells
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/2470950
Abstract: Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the hippocampus during Parkinson's disease… read more here.
Keywords: neutral sphingomyelinase; hippocampus; parkinson disease;
Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259324
Abstract: ABSTRACT During endosome maturation, neutral sphingomyelinase 2 (nSMase2, encoded by SMPD3) is involved in budding of intraluminal vesicles (ILVs) into late endosomes or multivesicular bodies (MVBs). Fusion of these with the plasma membrane results in… read more here.
Keywords: secretion; acidification; neutral sphingomyelinase; atpase ... See more keywords
Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.00217
Abstract: Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane. Upon specific ablation of NSM2, T cells… read more here.
Keywords: nsm2 deficient; stimulation; neutral sphingomyelinase; activation ... See more keywords
Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213935
Abstract: Flavivirus comprises globally emerging and re-emerging pathogens such as Zika virus (ZIKV), Dengue virus (DENV), and West Nile virus (WNV), among others. Although some vaccines are available, there is an unmet medical need as no… read more here.
Keywords: neutral sphingomyelinase; activity; binding site; sphingomyelinase nsmase2 ... See more keywords
Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032467
Abstract: Alterations of sphingolipids and their metabolizing enzymes play a role in various diseases. However, peripheral biomarkers for such changes are limited. Particularly, in the increasingly reported involvement of neutral sphingomyelinase (NSM) with four described isoforms… read more here.
Keywords: activity human; serum; nsm activity; neutral sphingomyelinase ... See more keywords