Sensitivity of two SARS-CoV-2 variants with spike protein mutations to neutralising antibodies
Sign Up to like & getrecommendations! Published in 2021 at "Virus Genes"
DOI: 10.1007/s11262-021-01871-8
Abstract: SARS-CoV-2 infections elicit a humoral immune response capable of neutralising the virus. However, multiple variants have emerged with mutations in the spike protein amongst others, the key target of neutralising antibodies. We evaluated the neutralising… read more here.
Keywords: protein mutations; sensitivity; spike protein; muc imb ... See more keywords
Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23233-6
Abstract: Assessment of the cumulative incidence of SARS-CoV-2 infections is critical for monitoring the course and extent of the COVID-19 epidemic. Here, we report estimated seroprevalence in the French population and the proportion of infected individuals… read more here.
Keywords: antibodies france; prevalence sars; france results; cov antibodies ... See more keywords
mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Vaccines"
DOI: 10.1038/s41541-021-00311-w
Abstract: mRNA technologies have recently proven clinical efficacy against coronavirus disease 2019 and are among the most promising technologies to address the current pandemic. Here, we show preclinical data for our clinical candidate CVnCoV, a lipid… read more here.
Keywords: candidate cvncov; virus neutralising; cvncov; sars cov ... See more keywords
Characterisation and application of recombinant FVIII‐neutralising antibodies from haemophilia A inhibitor patients
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17227
Abstract: The development of anti‐drug antibodies (ADAs) is a serious outcome of treatment strategies involving biological medicines. Coagulation factor VIII (FVIII) is used to treat haemophilia A patients, but its immunogenicity precludes a third of severe… read more here.
Keywords: application recombinant; fviii; characterisation application; fviii neutralising ... See more keywords
Methods for anti‐factor VIII antibody levels in haemophilia A patients – validation of a multiplex immunoassay and comparability with assays measuring non‐neutralising and neutralising antibodies (inhibitors)
Sign Up to like & getrecommendations! Published in 2022 at "Haemophilia"
DOI: 10.1111/hae.14669
Abstract: The development of neutralising (inhibitors) and non‐neutralising antibodies (NNAs) is a complication to factor replacement therapy in haemophilia. The diagnostic methods available lack standardisation, have high inter‐laboratory variation, and false‐negative as well as false‐positive results… read more here.
Keywords: anti factor; methods anti; factor viii; neutralising antibodies ... See more keywords
Ability of SpikoGen®, an Advax-CpG adjuvanted recombinant spike protein vaccine, to induce cross-neutralising antibodies against SARS-CoV-2 variants.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13661
Abstract: SpikoGen® vaccine is a subunit COVID-19 vaccine expressed in insect cells comprising recombinant spike protein extracellular domain formulated with Advax-CpG55.2™ adjuvant. A Phase 2 trial was conducted in 400 adult participants randomised 3:1 to receive… read more here.
Keywords: vaccine; spikogen; cross neutralising; neutralising antibodies ... See more keywords
Antibody response to feline herpesvirus-1 vaccination in healthy adult cats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x19845702
Abstract: Objectives Vaccination against feline herpesvirus-1 (FHV-1) is recommended for all cats. However, it is unknown how adult healthy cats with different pre-vaccination antibodies respond to FHV-1 vaccination in the field. The aim of the study… read more here.
Keywords: neutralising antibodies; feline herpesvirus; response; adult ... See more keywords
Detection of virus-neutralising antibodies and associated factors against rabies in the vaccinated household dogs of Kathmandu Valley, Nepal
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DOI: 10.1371/journal.pone.0231967
Abstract: Background Rabies is a vaccine-preventable neglected tropical viral zoonosis. It occurs worldwide, creating a very heavy burden in many developing countries, including Nepal. Dogs are the principle vector for the transmission of this disease in… read more here.
Keywords: dogs kathmandu; virus neutralising; factors rabies; associated factors ... See more keywords
An HIV-1/HIV-2 Chimeric Envelope Glycoprotein Generates Binding and Neutralising Antibodies against HIV-1 and HIV-2 Isolates
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24109077
Abstract: The development of immunogens that elicit broadly reactive neutralising antibodies (bNAbs) is the highest priority for an HIV vaccine. We have shown that a prime-boost vaccination strategy with vaccinia virus expressing the envelope glycoprotein gp120… read more here.
Keywords: hiv; envelope glycoprotein; chimeric envelope; neutralising antibodies ... See more keywords
Evidence of Infection with Zoonotic Mosquito-Borne Flaviviruses in Saltwater Crocodiles (Crocodylus porosus) in Northern Australia
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DOI: 10.3390/v14051106
Abstract: The risk of flavivirus infections among the crocodilian species was not recognised until West Nile virus (WNV) was introduced into the Americas. The first outbreaks caused death and substantial economic losses in the alligator farming… read more here.
Keywords: saltwater crocodiles; crocodylus porosus; crocodiles crocodylus; neutralising antibodies ... See more keywords
Rapid Quantification of SARS-CoV-2 Neutralising Antibodies Using Time-Resolved Fluorescence Immunoassay
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10122149
Abstract: The quantification of neutralising antibodies (NAb) for SARS-CoV-2 has become an important tool for monitoring protective immunity following infection or immunisation. In this study, we evaluated using World-Health-Organisation-standard immunoglobulin preparations, a novel point-of-care test that… read more here.
Keywords: neutralising antibodies; time resolved; rapid quantification; sars cov ... See more keywords