Biofunctionalized Liposomes to Monitor Rheumatoid Arthritis Regression Stimulated by Interleukin-23 Neutralization.
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DOI: 10.1002/adhm.202001570
Abstract: Even after the revolution of rheumatoid arthritis (RA) treatment with biologic agents, this debilitating disease remains a major clinical problem. The outstanding outcomes of the systemic administration of antibodies (Abs) are narrowed by the risk… read more here.
Keywords: liposomes monitor; neutralization biofunctionalized; neutralization; rheumatoid arthritis ... See more keywords
Omicron neutralization character in patients with breast cancer and liver cancer after the nationwide omicron outbreak
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DOI: 10.1002/cam4.7304
Abstract: The surge in omicron variants has caused nationwide breakthrough infections in mainland China since the December 2022. In this study, we report the neutralization profiles of serum samples from the patients with breast cancer and… read more here.
Keywords: cancer; breast cancer; neutralization; liver cancer ... See more keywords
Relationship Between Anifrolumab Pharmacokinetics, Pharmacodynamics, and Efficacy in Patients With Moderate to Severe Systemic Lupus Erythematosus
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DOI: 10.1002/jcph.2054
Abstract: This study aimed to elucidate the pharmacokinetic/pharmacodynamic and pharmacodynamic/efficacy relationships of anifrolumab, a type I interferon receptor antibody, in patients with moderate to severe systemic lupus erythematosus. Data were pooled from the randomized, 52‐week, placebo‐controlled… read more here.
Keywords: neutralization; efficacy; systemic lupus; lupus erythematosus ... See more keywords
Human seasonal coronavirus neutralization and COVID‐19 severity
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DOI: 10.1002/jmv.27937
Abstract: The virus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), responsible for the global coronavirus disease‐2019 (COVID‐19) pandemic, spread rapidly around the world causing high morbidity and mortality. However, there are four known, endemic seasonal coronaviruses… read more here.
Keywords: covid severity; coronavirus; neutralization; sars cov ... See more keywords
Key mutations in the spike protein of SARS‐CoV‐2 affecting neutralization resistance and viral internalization
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DOI: 10.1002/jmv.28407
Abstract: To control the ongoing COVID‐19 pandemic, a variety of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines have been developed. However, the rapid mutations of SARS‐CoV‐2 spike (S) protein may reduce the protective efficacy of… read more here.
Keywords: neutralization; key mutations; protective efficacy; spike protein ... See more keywords
Treatment with integrase inhibitors alters SARS‐CoV‐2 neutralization levels measured with HIV‐based pseudotypes in people living with HIV
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DOI: 10.1002/jmv.28543
Abstract: The presence of neutralizing antibodies (NAbs) is a major correlate of protection for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Thus, different in vitro pseudoviruses‐based assays have been described to detect NAbs against SARS‐CoV‐2.… read more here.
Keywords: hiv based; people living; neutralization; treatment ... See more keywords
Live‐virus neutralization of the omicron variant in children and adults 14 months after SARS‐CoV‐2 wild‐type infection
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DOI: 10.1002/jmv.28582
Abstract: Data on cross‐neutralization of the SARS‐CoV‐2 omicron variant more than 1 year after SARS‐CoV‐2 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective… read more here.
Keywords: omicron variant; infection; neutralization; sars cov ... See more keywords
Longer intervals between SARS‐CoV‐2 infection and mRNA‐1273 doses improve the neutralization of different variants of concern
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DOI: 10.1002/jmv.28679
Abstract: The humoral immune response against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants of concern elicited by vaccination was evaluated in COVID‐19 recovered individuals (Rec) separated 1–3 months (Rec2m) or 4–12 months (Rec9m) postinfection and… read more here.
Keywords: neutralization; variants concern; cov infection; response ... See more keywords
Consistent neutralization of circulating omicron sub‐variants by hybrid immunity up to 6 months after booster vaccination
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DOI: 10.1002/jmv.28694
Abstract: The current COVID‐19 vaccination program requires frequent booster vaccination to maintain sufficient neutralization levels against immune evasive SARS‐CoV‐2 variants. However, prior studies found more potent and durable immune response in convalescing individuals, raising the possibility… read more here.
Keywords: booster vaccination; circulating omicron; vaccination; convalescing individuals ... See more keywords
Dynamics of serum cross‐neutralization capacity against SARS‐CoV‐2 Delta variant in convalescent COVID‐19 patients
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DOI: 10.1002/jmv.29448
Abstract: The magnitude and breadth of the neutralizing antibody response against variants of concern following natural infection would provide valuable insights regarding the immune response induced by severe acute respiratory syndrome‐related coronavirus (SARS‐CoV‐2) infection. Herein, 25… read more here.
Keywords: sars cov; cross neutralization; visit; neutralization ... See more keywords
N121T and N121S substitutions on the SARS‐CoV‐2 spike protein impact on serum neutralization
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DOI: 10.1002/jmv.29871
Abstract: The N121 site on the spike protein of SARS‐CoV‐2 is associated with heme and its metabolite, biliverdin, which can affect antibody binding. Both N121T and N121S substitutions have been observed in natural conditions and in… read more here.
Keywords: sars cov; spike protein; n121t n121s; neutralization ... See more keywords