Development of Neutralization Breadth against Diverse HIV‐1 by Increasing Ab–Ag Interface on V2
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DOI: 10.1002/advs.202200063
Abstract: Understanding maturation pathways of broadly neutralizing antibodies (bnAbs) against HIV‐1 can be highly informative for HIV‐1 vaccine development. A lineage of J038 bnAbs is now obtained from a long‐term SHIV‐infected macaque. J038 neutralizes 54% of… read more here.
Keywords: neutralization breadth; development; hiv; development neutralization ... See more keywords
Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth
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DOI: 10.1371/journal.pone.0209437
Abstract: Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs in naturally infected individuals may be associated with high plasma viral loads, suggesting… read more here.
Keywords: hiv; antibody; breadth; neutralization ... See more keywords
HIV-1 infections with multiple founders associate with the development of neutralization breadth
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DOI: 10.1371/journal.ppat.1010369
Abstract: Eliciting broadly neutralizing antibodies (bnAbs) is a cornerstone of HIV-1 vaccine strategies. Comparing HIV-1 envelope (env) sequences from the first weeks of infection to the breadth of antibody responses observed several years after infection can… read more here.
Keywords: neutralization breadth; neutralization; hiv; development neutralization ... See more keywords
Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer
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DOI: 10.1371/journal.ppat.1010945
Abstract: Broadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subtypes and are able to prevent HIV-1 infection in animal models. However, bNAbs are extremely difficult to induce by vaccination. Defining the developmental… read more here.
Keywords: neutralization breadth; hiv; infected elite; antibody lineages ... See more keywords