Development of Neutralization Breadth against Diverse HIV‐1 by Increasing Ab–Ag Interface on V2
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200063
Abstract: Understanding maturation pathways of broadly neutralizing antibodies (bnAbs) against HIV‐1 can be highly informative for HIV‐1 vaccine development. A lineage of J038 bnAbs is now obtained from a long‐term SHIV‐infected macaque. J038 neutralizes 54% of… read more here.
Keywords: neutralization breadth; development; hiv; development neutralization ... See more keywords
Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0209437
Abstract: Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs in naturally infected individuals may be associated with high plasma viral loads, suggesting… read more here.
Keywords: hiv; antibody; breadth; neutralization ... See more keywords
HIV-1 infections with multiple founders associate with the development of neutralization breadth
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010369
Abstract: Eliciting broadly neutralizing antibodies (bnAbs) is a cornerstone of HIV-1 vaccine strategies. Comparing HIV-1 envelope (env) sequences from the first weeks of infection to the breadth of antibody responses observed several years after infection can… read more here.
Keywords: neutralization breadth; neutralization; hiv; development neutralization ... See more keywords
Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1010945
Abstract: Broadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subtypes and are able to prevent HIV-1 infection in animal models. However, bNAbs are extremely difficult to induce by vaccination. Defining the developmental… read more here.
Keywords: neutralization breadth; hiv; infected elite; antibody lineages ... See more keywords
Recapitulation of HIV-1 Neutralization Breadth in Plasma by the Combination of Two Broadly Neutralizing Antibodies from Different Lineages in the Same SHIV-Infected Rhesus Macaque
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25137200
Abstract: Viral infection generally induces polyclonal neutralizing antibody responses. However, how many lineages of antibody responses can fully represent the neutralization activities in sera has not been well studied. Using the newly designed stable HIV-1 Env… read more here.
Keywords: neutralization; antibodies different; neutralization breadth; broadly neutralizing ... See more keywords
Yeast Display Reveals Plentiful Mutations That Improve Fusion Peptide Vaccine-Elicited Antibodies Beyond 59% HIV-1 Neutralization Breadth
Sign Up to like & getrecommendations! Published in 2025 at "Vaccines"
DOI: 10.3390/vaccines13111098
Abstract: Background/Objectives: Vaccine elicitation of antibodies with high HIV-1 neutralization breadth is a long-standing goal. Recently, the induction of such antibodies has been achieved at the fusion peptide site of vulnerability. Questions remain, however, as to… read more here.
Keywords: fusion peptide; breadth; yeast display; neutralization breadth ... See more keywords