Structure‐based discovery of small molecules improving stability of human broadly‐neutralizing anti‐HIV antibody 2F5 in plant suspension cells
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DOI: 10.1002/biot.202100266
Abstract: The production of biopharmaceuticals in engineered plant‐based systems is a promising technology that has proven its suitability for the production of various recombinant glyco–proteins that are currently undergoing clinical trials. However, compared to mammalian cell… read more here.
Keywords: broadly neutralizing; human broadly; neutralizing anti; anti hiv ... See more keywords
Mechanisms of Neutralizing Anti-drug Antibody Formation and Clinical Relevance on Therapeutic Efficacy of Enzyme Replacement Therapies in Fabry Disease
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DOI: 10.1007/s40265-021-01621-y
Abstract: Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (AGAL/GLA) gene. The lysosomal accumulation of the substrates globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) results in progressive renal failure,… read more here.
Keywords: enzyme replacement; fabry disease; disease; neutralizing anti ... See more keywords
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR
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DOI: 10.1038/s41598-019-48592-5
Abstract: The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved… read more here.
Keywords: hcv antibodies; hcv; hiv hcv; neutralizing anti ... See more keywords
Identification of non‐neutralizing anti‐factor X autoantibodies in three Japanese cases of autoimmune acquired factor X deficiency
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DOI: 10.1111/hae.14711
Abstract: Autoimmune factor X (FX or F10) deficiency (AiF10D) is an extremely rare acquired haemorrhagic disorder characterized by a severe reduction in FX activity due to autoantibodies against FX. read more here.
Keywords: non neutralizing; anti factor; identification non; neutralizing anti ... See more keywords
Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis
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DOI: 10.3389/fonc.2021.780191
Abstract: Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm characterised by the accumulation into granulomas of apoptosis-resistant pathological dendritic cells (LCH-DCs). LCH outcome ranges from self-resolving to fatal. Having previously shown that, (i) monocyte-derived DCs… read more here.
Keywords: lch patients; dcs lch; neutralizing anti; expression ... See more keywords