Analytical characterization of broadly neutralizing antibody CAP256LS heavy chain clipping during manufacturing development
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DOI: 10.1002/btpr.3296
Abstract: Broadly neutralizing antibody (bNAb) CAP256‐VRC26.25 (abbreviated CAP256LS), a human IgGI monoclonal antibody targeting the V1V2 site of the HIV‐1 envelope, has demonstrated high therapeutic potential as a broadly neutralizing monoclonal antibody against HIV‐1. During the… read more here.
Keywords: heavy chain; analytical characterization; broadly neutralizing; development ... See more keywords
Neutralizing antibody responses 300 days after SARS‐CoV‐2 infection and induction of high antibody titers after vaccination
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DOI: 10.1002/eji.202149758
Abstract: Neutralizing antibodies against SARS‐CoV‐2 are important to protect against infection and/or disease. Using an assay to detect antibodies directed against the receptor binding domain (RBD) of SARS‐CoV‐2 Spike, we identified individuals with SARS‐CoV‐2 infection after… read more here.
Keywords: infection; antibody titers; neutralizing antibody; antibody ... See more keywords
Sclerostin‐Neutralizing Antibody Treatment Rescues Negative Effects of Rosiglitazone on Mouse Bone Parameters
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DOI: 10.1002/jbmr.4170
Abstract: Obesity, a growing pandemic, is a risk factor for many cancers and causes increased bone marrow adipose tissue (BMAT). in vitro studies and obese animal models suggest that BMAT contributes to cancer progression, but there… read more here.
Keywords: sclerostin neutralizing; neutralizing antibody; bmat; bone ... See more keywords
The protective effect of IL‐12/23 neutralizing antibody in sarcopenia associated with dextran sulfate sodium‐induced experimental colitis
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DOI: 10.1002/jcsm.13208
Abstract: The improvement of colitis symptoms by treatment with IL‐12/23 p40 neutralizing antibody should increase the muscle mass and the function of the sarcopenia phenotype. read more here.
Keywords: colitis; protective effect; effect neutralizing; neutralizing antibody ... See more keywords
Investigation and long‐term monitoring of the presence of neutralizing antibody in patients with COVID‐19 disease of different clinical severity
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DOI: 10.1002/jmv.27751
Abstract: Understanding the immune responses elicited by severe acute respiratory syndrome virus (SARS‐CoV‐2) infection is critical to public health policy and vaccine development and prevention of reinfections for COVID‐19. It is important to know the neutralizing… read more here.
Keywords: clinical severity; severity; neutralizing antibody; patients covid ... See more keywords
Clinical observation of neutralizing antibody DXP‐604 for treatment critical COVID‐19 patients infected with SARS‐CoV‐2 Delta variant
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DOI: 10.1002/jmv.28742
Abstract: From January to March 2022, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Delta (B.1.617.2) infection was prevalent in Yuzhou and Zhengzhou. DXP‐604 is a broad‐spectrum antiviral monoclonal antibody, which has excellent viral neutralization ability in… read more here.
Keywords: dxp 604; cov delta; neutralizing antibody; treatment ... See more keywords
Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine
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DOI: 10.1007/s00439-017-1768-9
Abstract: Population-based studies have revealed 2–10% measles vaccine failure rate even after two vaccine doses. While the mechanisms behind this remain unknown, we hypothesized that host genetic factors are likely to be involved. We performed a… read more here.
Keywords: genome wide; response; measles vaccine; neutralizing antibody ... See more keywords
Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain
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DOI: 10.1007/s15010-020-01556-8
Abstract: Background We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. Case One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low… read more here.
Keywords: sars cov; neutralizing antibody; infection; cov strain ... See more keywords
SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses
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DOI: 10.1016/j.cell.2022.01.011
Abstract: Although infections among vaccinated individuals lead to milder COVID-19 symptoms relative to unvaccinated subjects, the specificity and durability of antibody responses elicited by breakthrough cases remain unknown. Here, we demonstrate that breakthrough infections induce serum… read more here.
Keywords: sars cov; cov breakthrough; neutralizing antibody; antibody ... See more keywords
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
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DOI: 10.1016/j.celrep.2022.110368
Abstract: Emerging evidence indicate that both neutralizing and Fc-mediated effector functions of antibodies contribute to protection against SARS-CoV-2. It is unclear if Fc-effector functions alone can protect against SARS-CoV-2. Here, we isolated CV3-13, a non-neutralizing antibody,… read more here.
Keywords: sars cov; non neutralizing; delays virus; neutralizing antibody ... See more keywords
Neutralizing antibody response to SARS-CoV-2 persists 9 months post symptom onset in mild and asymptomatic patients
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DOI: 10.1016/j.ijid.2021.09.002
Abstract: Objective A better understanding of immune response against SARS-CoV-2 infection is critical to predict its dynamics within general population and its impact on vaccination strategy. We assessed both neutralizing antibody (Nab) activity persistence and SARS-CoV-2… read more here.
Keywords: neutralizing antibody; serology; response sars; mild asymptomatic ... See more keywords