Modification of neutralizing epitopes of hemagglutinin for the development of broadly protective H9N2 vaccine.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.11.080
Abstract: The H9N2 avian influenza viruses cause significant economic losses in poultry worldwide and could potentially cause human pandemic. Currently, the available vaccines have limited efficacy due to antigenic drift of H9N2. To improve vaccine efficacy,… read more here.
Keywords: neutralizing epitopes; h9n2 vaccine; epitopes hemagglutinin; modification neutralizing ... See more keywords
Protective neutralizing epitopes in SARS‐CoV‐2
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DOI: 10.1111/imr.13084
Abstract: The COVID‐19 pandemic has caused an unprecedented health crisis and economic burden worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has infected hundreds of millions of people worldwide. SARS‐CoV‐2 has evolved… read more here.
Keywords: epitopes sars; infection; neutralizing epitopes; protective neutralizing ... See more keywords
Mapping the Neutralizing Epitopes of Enterotoxigenic Escherichia coli K88 (F4) Fimbrial Adhesin and Major Subunit FaeG
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DOI: 10.1128/aem.00329-19
Abstract: Enterotoxigenic Escherichia coli (ETEC) strains producing K88ac fimbriae and enterotoxins are a major cause of porcine neonatal diarrhea and postweaning diarrhea in the United States. Currently, there is no vaccine to induce broadly protective antiadhesin… read more here.
Keywords: neutralizing epitopes; diarrhea; escherichia coli; enterotoxigenic escherichia ... See more keywords
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies
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DOI: 10.3389/fimmu.2022.978858
Abstract: Toxin A (TcdA) and toxin B (TcdB) are two key virulence factors secreted by Clostridioides difficile, which is listed as an urgent threat by the CDC. These two large homologous exotoxins are mainly responsible for… read more here.
Keywords: difficile toxin; epitopes clostridioides; clostridioides difficile; neutralizing epitopes ... See more keywords
A Fast and Inexpensive Protocol for Empirical Verification of Neutralizing Epitopes in Microbial Toxins and Enzymes
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DOI: 10.3389/fvets.2017.00091
Abstract: In vivo targeting of peptides to antigen-presenting cells by use of agonistic anti-CD40 monoclonal antibodies has been used successfully as an immune response enhancing strategy. When tested in chickens, the antibody-guided platform was capable of… read more here.
Keywords: neutralizing epitopes; epitopes microbial; antibody guided; toxin ... See more keywords
Flexible RSV Prefusogenic Fusion Glycoprotein Exposes Multiple Neutralizing Epitopes that May Collectively Contribute to Protective Immunity
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DOI: 10.3390/vaccines8040607
Abstract: Human respiratory syncytial virus (RSV) is a cause of lower respiratory tract infection in infants, young children, and older adults. There is no licensed vaccine and prophylactic treatment options are limited. The RSV fusion (F)… read more here.
Keywords: neutralizing epitopes; immunity; may collectively; prefusion ... See more keywords