Neutralizing Mutations Significantly Inhibit Amyloid Formation by Human Prion Protein and Decrease Its Cytotoxicity.
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DOI: 10.1016/j.jmb.2019.11.020
Abstract: Prion diseases, such as Creutzfeldt-Jakob disease and bovine spongiform encephalopathy, are fatal neurodegenerative diseases that affect many mammals including humans, and are caused by the misfolding of prion protein (PrP). A naturally occurring protective polymorphism… read more here.
Keywords: formation human; neutralizing mutations; prion; formation ... See more keywords