Interfacial Assembly Inspired by Marine Mussels and Antifouling Effects of Polypeptoids: A Neutron Reflection Study
Sign Up to like & getrecommendations! Published in 2020 at "Langmuir"
DOI: 10.1021/acs.langmuir.0c02247
Abstract: Polypeptoid-coated surfaces and many surface-grafted hydrophilic polymer brushes have been proven efficient in antifouling-the prevention of nonspecific biomolecular adsorption and cell attachment. Protein adsorption, in particular, is known to mediate subsequent cell-surface interactions. However, the… read more here.
Keywords: neutron reflection; adsorption; polymer; interfacial assembly ... See more keywords
Investigating the Orientation of an Interfacially Adsorbed Monoclonal Antibody and Its Fragments Using Neutron Reflection
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00864
Abstract: Interfacial adsorption is a molecular process occurring during the production, purification, transport, and storage of antibodies, with a direct impact on their structural stability and subsequent implications on their bioactivities. While the average conformational orientation… read more here.
Keywords: orientation; neutron reflection; water; monoclonal antibody ... See more keywords
Neutron Reflection Study of Surface Adsorption of Fc, Fab, and the Whole mAb.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b06131
Abstract: Characterizing the influence of fragment crystallization (Fc) and antigen-binding fragment (Fab) on monoclonal antibody (mAb) adsorption at the air/water interface is an important step to understanding liquid mAb drug product stability during manufacture, shipping, and… read more here.
Keywords: neutron reflection; adsorption; surface; amount ... See more keywords