Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection
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DOI: 10.1093/jac/dky404
Abstract: Objectives The neutropenic murine thigh infection model and a dose-fractionation approach were used to determine the pharmacokinetic/pharmacodynamic (PK/PD) relationship of LYS228, a novel monobactam antibiotic with activity against Enterobacteriaceae including carbapenem-resistant strains. Methods Mice (n = 4… read more here.
Keywords: murine; infection; neutropenic murine; model ... See more keywords
In Vivo Pharmacokinetic/Pharmacodynamic Targets of Levonadifloxacin against Staphylococcus aureus in a Neutropenic Murine Lung Infection Model
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DOI: 10.1128/aac.00909-19
Abstract: Levonadifloxacin is a novel benzoquinolizine subclass of fluoroquinolone, active against quinolone-resistant Staphylococcus aureus. A phase 3 trial for levonadifloxacin and its oral prodrug was recently completed. The present study identified area under the concentration-time curve… read more here.
Keywords: neutropenic murine; murine lung; staphylococcus aureus; lung infection ... See more keywords
Pharmacodynamics of Temocillin in Neutropenic Murine Infection Models
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DOI: 10.1128/aac.01433-22
Abstract: Temocillin is used for the treatment of various infections caused by Enterobacterales. The pharmacokinetic (PK)/pharmacodynamic (PD) index that is best correlated with the activity of beta-lactams is the percentage of time that the unbound concentration… read more here.
Keywords: infection models; pneumoniae; infection; lung infection ... See more keywords