Real-Time Micromotor Probe for Immune Neutrophil Activation State.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300737
Abstract: Neutrophil activation is a hallmark of the immune response. Approaches to identify neutrophil activation in real time are necessary but are still lacking. In this study, magnetic Spirulina micromotors were used as label-free probes that exhibit… read more here.
Keywords: activation state; real time; activation; neutrophil activation ... See more keywords
Histone H4 directly stimulates neutrophil activation through membrane permeabilization
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0620-342r
Abstract: Extracellular histones have been implicated as a cause of tissue inflammatory injury in a variety of disorders including sepsis, lung, and liver diseases. However, little is known about their interactions with neutrophils and how this… read more here.
Keywords: activation; neutrophil activation; permeabilization; histone directly ... See more keywords
Janus face of complement-driven neutrophil activation during sepsis.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in immunology"
DOI: 10.1016/j.smim.2018.02.004
Abstract: During local and systemic inflammation, the complement system and neutrophil granulocytes are activated not only by pathogens, but also by released endogenous danger signals. It is recognized increasingly that complement-mediated neutrophil activation plays an ambivalent… read more here.
Keywords: sepsis; janus face; face complement; neutrophil activation ... See more keywords
Selective neutrophil activation via a programmable stopped-flow injection approach: Multiple evidences of priming state of salivary polymorphonuclear neutrophils compared to circulatory polymorphonuclear neutrophils.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2020.121449
Abstract: Activated polymorphonuclear neutrophils play an important role in host defense system against invading pathogens via releasing reactive oxygen species through respiratory bursts. Nowadays, neutrophil activation process has been found to be modeled as a two-stages… read more here.
Keywords: polymorphonuclear; neutrophil activation; priming state; salivary polymorphonuclear ... See more keywords
Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09160-7
Abstract: Heparin-induced thrombocytopenia/thrombosis (HIT) is a serious immune reaction to heparins, characterized by thrombocytopenia and often severe thrombosis with high morbidity and mortality. HIT is mediated by IgG antibodies against heparin/platelet factor 4 antigenic complexes. These… read more here.
Keywords: heparin; netosis; neutrophil activation; induced thrombocytopenia ... See more keywords
Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19
Sign Up to like & getrecommendations! Published in 2023 at "Virulence"
DOI: 10.1080/21505594.2023.2218077
Abstract: ABSTRACT Neutrophil dysregulation is well established in COVID-19. However, factors contributing to neutrophil activation in COVID-19 are not clear. We assessed if N-formyl methionine (fMet) contributes to neutrophil activation in COVID-19. Elevated levels of calprotectin,… read more here.
Keywords: neutrophil activation; activation covid; formyl methionine; patients covid ... See more keywords
Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low-density granulocytes
Sign Up to like & getrecommendations! Published in 2018 at "Rheumatology"
DOI: 10.1093/rheumatology/kex441
Abstract: Objective JIA is an autoimmune, inflammatory disease with involvement of innate and adaptive immune responses. However, the role of neutrophils in JIA pathogenesis remains unclear. This study aimed to identify and validate neutrophil gene expression… read more here.
Keywords: jia; neutrophil activation; jia pbmcs; low density ... See more keywords
Targeting of neutrophil activation in the early phase of the disease for prevention of Coronavirus disease-19 severity.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology and immunology"
DOI: 10.1111/1348-0421.12978
Abstract: Prevention of the disease severity seems critical for mortality reduction of Coronavirus (CoV) disease-19. The neutrophils play a key role in the induction of severity. We here propose inhibition of neutrophil activation and/or cascade reactions… read more here.
Keywords: neutrophil activation; activation early; disease severity; disease ... See more keywords
Neutrophil dysfunction due to continuous mechanical shear exposure in mechanically assisted circulation in vitro.
Sign Up to like & getrecommendations! Published in 2021 at "Artificial organs"
DOI: 10.1111/aor.14068
Abstract: OBJECTIVE Leukocytes play an important role in the body's immune system. The aim of this study was to assess alterations in neutrophil phenotype and function in pump-assisted circulation in-vitro. METHODS Human blood was circulated for… read more here.
Keywords: circulation vitro; pump; neutrophil activation; assisted circulation ... See more keywords
FRI0357 Microparticles as a biomarker and a redox-dependent regulator of neutrophil activation and proteolytic activity in patients with systemic sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.3980
Abstract: Background Persistent oxidative stress and unrelenting vascular inflammation are hallmarks of Systemic Sclerosis (SSc). Platelet-derived microparticles (PD-uP) that express a bioactive redox-dependent moiety, HMGB1 accumulate in the peripheral blood of patients with SSc. Objectives To… read more here.
Keywords: hmgb1; ssc patients; ssc; neutrophil activation ... See more keywords
OP0300 A NEUTROPHIL SIGNATURE IS STRONGLY ASSOCIATED WITH CARDIOVASCULAR RISK IN GOUT
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4793
Abstract: Background Similar to other rheumatic diseases, patients with gout have an increased cardiovascular morbidity and mortality, not fully explained by traditional cardiovascular risk factors. Instead, gout-specific factors, including xanthine oxidase induced oxidative stress, increased lipid… read more here.
Keywords: risk; neutrophil activation; cardiovascular risk; signature ... See more keywords