Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33851-8
Abstract: Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave… read more here.
Keywords: degranulation; pltp; kinase; aat ... See more keywords
Abstract 369: Infarct Macrophage Secretome Factors Regulate Neutrophil Degranulation
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.369
Abstract: Following myocardial infarction (MI), the left ventricle undergoes wound healing that begins withan intense inflammatory response to recruit leukocytes to the infarcted region. Infiltratedneutrophils degranulate, releasing a series of proteases including matrix metalloproteinase(MMP)-9 into the… read more here.
Keywords: degranulation; effect; macrophage secretome; factors regulate ... See more keywords
Quantitative tissue proteome profile reveals neutrophil degranulation and remodeling of extracellular matrix proteins in early stage gallbladder cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1046974
Abstract: Gallbladder cancer (GBC) is an aggressive malignancy of the gastrointestinal tract with a poor prognosis. It is important to understand the molecular processes associated with the pathogenesis of early stage GBC and identify proteins useful… read more here.
Keywords: early stage; gbc; neutrophil degranulation; stage ... See more keywords
SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020382
Abstract: SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as an important correlate to poor recovery rates in severe COVID-19… read more here.
Keywords: cov dysregulates; dysregulates neutrophil; lymphocyte counts; neutrophil degranulation ... See more keywords
The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host
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DOI: 10.3390/ijms21041183
Abstract: Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation and the release of neutrophil extracellular traps;… read more here.
Keywords: degranulation; hypoxia neutrophil; impact hypoxia; host ... See more keywords
Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021038
Abstract: Cervical mucus (CM) is a viscous fluid that is produced by the cervical glands and functions as a uterine cervix plug. Its viscosity decreases during ovulation, providing a window for non-invasive sampling. This study focuses… read more here.
Keywords: source biomarkers; cervical mucus; neutrophil degranulation; tract ... See more keywords