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   Articles with "neutrophil elastase" as a keyword



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New 3‐unsubstituted isoxazolones as potent human neutrophil elastase inhibitors: Synthesis and molecular dynamic simulation

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recommendations! Published in 2019 at "Drug Development Research"

DOI: 10.1002/ddr.21625

Abstract: Human neutrophil elastase (HNE) is a proteolytic enzyme belonging to the serine protease family and is involved in a variety of pathologies. Thus, compounds able to inhibit HNE represent promising therapeutics for the treatment of… read more here.

Keywords: unsubstituted isoxazolones; human neutrophil; neutrophil elastase; new unsubstituted ... See more keywords
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Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide

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recommendations! Published in 2022 at "Protein Science"

DOI: 10.1002/pro.4274

Abstract: Human neutrophil elastase (hNE) is an abundant serine protease that is a major constituent of lung elastolytic activity. However, when secreted in excess, if not properly attenuated by selective inhibitor proteins, it can have detrimental… read more here.

Keywords: ecotin; inhibition; sequence; neutrophil elastase ... See more keywords
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Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors

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recommendations! Published in 2021 at "Medicinal Chemistry Research"

DOI: 10.1007/s00044-020-02684-4

Abstract: Herein we report our investigation concerning the development of Human neutrophil elastase (hNE) inhibitors for the treatment of Acute Respiratory Distress Syndrome (ARDS). Various benzenesulfonic acid derived compounds were synthesized and evaluated as competitive inhibitors… read more here.

Keywords: benzenesulfonic acid; neutrophil elastase; human neutrophil; hne ... See more keywords
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Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects

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recommendations! Published in 2018 at "Molecular Biology Reports"

DOI: 10.1007/s11033-018-4279-4

Abstract: Neutrophil elastase and myeloperoxidase enzymes have been implicated in high-fat diet-induced obesity, insulin resistance (IR) and atherosclerosis in animal models. The aim of the present study was to explore neutrophil elastase and myeloperoxidase mRNA expressions… read more here.

Keywords: overweight obese; myeloperoxidase; elastase myeloperoxidase; myeloperoxidase mrna ... See more keywords
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Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock.

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recommendations! Published in 2020 at "Biomaterials"

DOI: 10.1016/j.biomaterials.2020.119836

Abstract: Neutrophil elastase (NE) is a serine protease stored in the azurophilic granules of neutrophils and released into the extracellular milieu during inflammatory response or formation of neutrophil extracellular traps (NETs). Neutrophils release NETs to entrap… read more here.

Keywords: neutrophil extracellular; formation; neutrophil elastase; endotoxic shock ... See more keywords
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Competitive neutrophil elastase inhibitory isoflavones from the roots of Flemingia philippinensis.

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recommendations! Published in 2018 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2018.03.024

Abstract: Flemingia philippinensis has been used throughout history to cure rheumatism associated with neutrophil elastase (NE). In this study, we isolated sixteen NE inhibitory flavonoids (1-16), including the most potent and abundant prenyl isoflavones (1-9), from… read more here.

Keywords: philippinensis; competitive neutrophil; flemingia philippinensis; elastase inhibitory ... See more keywords
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Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

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recommendations! Published in 2021 at "Cell"

DOI: 10.1016/j.cell.2021.04.016

Abstract: Cancer cell genetic variability and similarity to host cells have stymied development of broad anti-cancer therapeutics. Our innate immune system evolved to clear genetically diverse pathogens and limit host toxicity; however, whether/how innate immunity can… read more here.

Keywords: neutrophil elastase; cancer cells; cancer; cell ... See more keywords
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Severe Pulmonary Arterial Hypertension is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.

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recommendations! Published in 2021 at "Chest"

DOI: 10.1016/j.chest.2021.06.028

Abstract: BACKGROUND Preclinical evidence implicates neutrophil elastase (NE) in PAH pathogenesis, and the NE inhibitor elafin is under early therapeutic investigation. RESEARCH QUESTION Are circulating NE and elafin levels abnormal in PAH and associated with clinical… read more here.

Keywords: severe pulmonary; elafin; pulmonary arterial; neutrophil elastase ... See more keywords
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Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance

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recommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"

DOI: 10.1016/j.ejpb.2018.01.011

Abstract: Graphical abstract Figure. No caption available. HighlightsER143‐loaded StNC proved as a strategy to improve ER143 pharmaceutical performance.ER143‐loaded StNC showed an improved anti‐inflammatory effect.A QbD approach was successfully applied to obtain ER143‐loaded StNC. &NA; Psoriasis and… read more here.

Keywords: pharmaceutical performance; elastase inhibitor; neutrophil elastase; improved pharmaceutical ... See more keywords
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An elastase activity reporter for Electronic Paramagnetic Resonance (EPR) and Overhauser‐enhanced Magnetic Resonance Imaging (OMRI) as a line‐shifting nitroxide

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.08.006

Abstract: Abstract Pulmonary inflammatory diseases are a major burden worldwide. They have in common an influx of neutrophils. Neutrophils secrete unchecked proteases at inflammation sites consequently leading to a protease/inhibitor imbalance. Among these proteases, neutrophil elastase… read more here.

Keywords: resonance; elastase; neutrophil elastase; spectroscopy ... See more keywords
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Polysaccharides from Kochia scoparia fruits protect mice from lipopolysaccharide-mediated acute lung injury by inhibiting neutrophil elastase

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recommendations! Published in 2017 at "Journal of Functional Foods"

DOI: 10.1016/j.jff.2017.09.060

Abstract: Abstract Acute lung injury (ALI) is a respiratory disease that is associated with neutrophil activation. Neutrophil elastase released from activated neutrophils has been reported to cause lung tissue damage and contribute to the inflammatory response… read more here.

Keywords: elastase; neutrophil elastase; kochia scoparia; lung injury ... See more keywords