Microglial IL‐1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1‐mediated neutrophil recruitment and microvessel occlusion
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DOI: 10.1002/glia.24359
Abstract: Acute ischemic stroke (AIS), one of the leading causes of mortality worldwide, is characterized by a rapid inflammatory cascade resulting in exacerbation of ischemic brain injury. Microglia are the first immune responders. However, the role… read more here.
Keywords: cxcl1; neutrophil recruitment; brain; brain injury ... See more keywords
Intravital Imaging Reveals the Ameliorating Effect of Colchicine in a Photothrombotic Stroke Model via Inhibition of Neutrophil Recruitment.
Sign Up to like & getrecommendations! Published in 2022 at "Translational stroke research"
DOI: 10.1007/s12975-022-01022-7
Abstract: Although post-stroke neutrophil recruitment is known to be deleterious to neural tissues in the peri-infarct area, the precise behavior of recruited neutrophils remains elusive. In this study, potential therapeutic agents for modifying neutrophil behavior in… read more here.
Keywords: stroke; colchicine; model; neutrophil recruitment ... See more keywords
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
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DOI: 10.1016/j.cell.2020.11.007
Abstract: SARS-CoV-2 induced hypercytokinemia and inflammation are critically associated with COVID-19 disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor, is currently being investigated in COVID-19 clinical trials. Here, we investigated the immunologic and virologic efficacy of… read more here.
Keywords: inflammation neutrophil; rhesus; neutrophil recruitment; inflammation ... See more keywords
A Liver Capsular Network of Monocyte‐Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.07.018
Abstract: &NA; The liver is positioned at the interface between two routes traversed by pathogens in disseminating infection. Whereas blood‐borne pathogens are efficiently cleared in hepatic sinusoids by Kupffer cells (KCs), it is unknown how the… read more here.
Keywords: network; neutrophil recruitment; recruitment; liver capsular ... See more keywords
Clostridioides difficile aggravates dextran sulfate solution (DSS)-induced colitis by shaping the gut microbiota and promoting neutrophil recruitment
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2192478
Abstract: ABSTRACT Clostridioides difficile is a pathogen contributing to increased morbidity and mortality of patients with inflammatory bowel disease (IBD). To determine how C. difficile affects the severity of colitis, we constructed a dextran sulfate solution-induced… read more here.
Keywords: clostridioides difficile; colitis; neutrophil recruitment; microbiota ... See more keywords
Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis
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DOI: 10.1097/ico.0000000000001756
Abstract: Purpose: Fungal keratitis is a major cause of corneal ulcers, resulting in significant visual impairment and blindness. Fenretinide, a derivative of vitamin A, has been shown to suppress inflammation in a multitude of diseases. In… read more here.
Keywords: aspergillus fumigatus; production; fumigatus keratitis; neutrophil recruitment ... See more keywords
Red Blood Cells Elicit Platelet-Dependent Neutrophil Recruitment Into Lung Airspaces
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DOI: 10.1097/shk.0000000000001705
Abstract: ABSTRACT Hemolysis that occurs in intravascular hemolytic disorders, such as sickle cell disease and malaria, is associated with inflammation and platelet activation. Alveolar hemorrhage, for example following primary blast lung injury or acute respiratory distress… read more here.
Keywords: platelet dependent; lung; platelet; neutrophil recruitment ... See more keywords
The Bruton's tyrosine kinase inhibitor PRN473 inhibits neutrophil recruitment via inhibition of Mac-1 signaling
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DOI: 10.1111/bph.14090
Abstract: Background and Purpose Following inflammatory stimuli neutrophils are recruited to sites of inflammation and exert effector functions that often have deleterious effects on tissue integrity, which can lead to organ failure. Btk is expressed in… read more here.
Keywords: prn473; inhibitor; neutrophil recruitment; inhibition ... See more keywords
GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation.
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DOI: 10.1111/imr.13194
Abstract: Neutrophil recruitment from circulation to sites of inflammation is guided by multiple chemoattractant cues emanating from tissue cells, immune cells, and platelets. Here, we focus on the function of one G-protein coupled receptor, GPR35, in… read more here.
Keywords: gpr35; inflammation; platelets mast; neutrophil recruitment ... See more keywords
The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage.
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DOI: 10.1182/blood-2017-04-777680
Abstract: CCRL2 is a 7-transmembrane domain receptor that shares structural and functional similarities with the family of atypical chemokine receptors (ACKRs). CCRL2 is upregulated by inflammatory signals and, unlike other ACKRs, it is not a chemoattractant-scavenging… read more here.
Keywords: ccrl2; atypical receptor; neutrophil recruitment; receptor ccrl2 ... See more keywords
NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function
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DOI: 10.1371/journal.ppat.1007308
Abstract: Gram-positive bacteria, including Staphylococcus aureus are endemic in the U.S., which cause life-threatening necrotizing pneumonia. Neutrophils are known to be critical for clearance of S. aureus infection from the lungs and extrapulmonary organs. Therefore, we… read more here.
Keywords: gram positive; neutrophil recruitment; infection; host defense ... See more keywords