Neutrophilic Asthma.
Sign Up to like & getrecommendations! Published in 2018 at "Archivos de bronconeumologia"
DOI: 10.1016/j.arbres.2017.11.018
Abstract: The goal of systems or personalized medicine is to deliver the optimal drug to the right patient at the right time.1,2 A prerequisite for this is the correct identification of asthma clinical phenotypes that possess… read more here.
Keywords: neutrophilic asthma; th2;
Tunicamycin aggravates endoplasmic reticulum stress and airway inflammation via PERK-ATF4-CHOP signaling in a murine model of neutrophilic asthma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asthma"
DOI: 10.1080/02770903.2016.1205085
Abstract: Abstract Introduction: Endoplasmic reticulum (ER) stress has been considered to be an important regulator of airway inflammation in the pathogenesis of bronchial asthma, but the mechanism of ER stress involved in neutrophilic asthma remain not… read more here.
Keywords: neutrophilic asthma; stress; inflammation; atf4 chop ... See more keywords
Role of IL-22 in acute asthma mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma"
DOI: 10.1080/02770903.2022.2155186
Abstract: Abstract Introduction: Allergic asthma is often associated with eosinophilic inflammation, which is related to the T-helper cell type 2 (Th2) cytokines and responsive to corticosteroids. However, there are also phenotypes of non-Th2-mediated asthma, which have… read more here.
Keywords: ova ova; asthma; neutrophilic asthma; asthma mouse ... See more keywords
sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma.
Sign Up to like & getrecommendations! Published in 2021 at "Immunological investigations"
DOI: 10.1080/08820139.2021.1928183
Abstract: Background: Neutrophilic asthma (NA) may result in irreversible airflow limitations. Soluble advanced glycosylation receptor (sRAGE) has been shown to be associated with neutrophilic airway inflammation. However, the association between sRAGE and mucus hypersecretion in NA… read more here.
Keywords: neutrophilic asthma; mouse model; srage; mucus hypersecretion ... See more keywords
Luteolin alleviated neutrophilic asthma by inhibiting IL-36γ secretion-mediated MAPK pathways
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2160770
Abstract: Abstract Context Luteolin can affect multiple biological functions, such as anti-inflammatory, antioxidant and immune enhancement processes. Luteolin can inhibit inflammation of T2-high asthma, but its role in neutrophilic asthma has been insufficently studied. Objective This… read more here.
Keywords: luteolin; neutrophilic asthma; secretion; mediated mapk ... See more keywords
Synergistic effect of roflumilast with dexamethasone in a neutrophilic asthma mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13635
Abstract: Asthma is a chronic airway inflammatory disease with heterogeneous features. Most cases of asthma are steroid sensitive, but 5%‐10% are unresponsive to steroids, leading to challenges in treatment. Neutrophilic asthma is steroid‐resistant and characterized by… read more here.
Keywords: asthma; rof; neutrophilic asthma; asthma mouse ... See more keywords
The onset, development and pathogenesis of severe neutrophilic asthma
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12522
Abstract: Bronchial asthma is divided into Th2 high, Th2 low and mixed types. The Th2 high type is dominated by eosinophils while the Th2 low type is divided into neutrophilic and paucigranulocytic types. Eosinophilic asthma has… read more here.
Keywords: asthma; neutrophilic asthma; severe neutrophilic; treatment neutrophilic ... See more keywords
Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.849155
Abstract: Rationale Non-allergic asthma is driven by multiple endotypes of which neutrophilic and pauci-granulocytic asthma have been best established. However, it is still puzzling what drives inflammation and airway hyperreactivity (AHR) in these patients and how… read more here.
Keywords: murine; asthma; model; neutrophilic asthma ... See more keywords
YKL-40 as a possible marker of neutrophilic asthma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1115938
Abstract: Asthma is a heterogeneous chronic disorder of the airways, with inflammation and bronchial hyperresponsiveness as its major underlying phenomena. Asthmatics vary in terms of inflammation pattern, concomitant pathologies, and factors aggravating the course of the… read more here.
Keywords: ykl possible; possible marker; asthma; marker neutrophilic ... See more keywords
Identification of Key Signaling Pathways and Genes in Eosinophilic Asthma and Neutrophilic Asthma by Weighted Gene Co-Expression Network Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.805570
Abstract: Background: Asthma is a heterogeneous disease with different subtypes including eosinophilic asthma (EA) and neutrophilic asthma (NA). However, the mechanisms underlying the difference between the two subtypes are not fully understood. Methods: Microarray datasets (GSE45111… read more here.
Keywords: neutrophilic asthma; analysis; gene expression; signaling pathways ... See more keywords