Neutrophilic Asthma.
Sign Up to like & getrecommendations! Published in 2018 at "Archivos de bronconeumologia"
DOI: 10.1016/j.arbres.2017.11.018
Abstract: The goal of systems or personalized medicine is to deliver the optimal drug to the right patient at the right time.1,2 A prerequisite for this is the correct identification of asthma clinical phenotypes that possess… read more here.
Keywords: neutrophilic asthma; th2;
Tunicamycin aggravates endoplasmic reticulum stress and airway inflammation via PERK-ATF4-CHOP signaling in a murine model of neutrophilic asthma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asthma"
DOI: 10.1080/02770903.2016.1205085
Abstract: Abstract Introduction: Endoplasmic reticulum (ER) stress has been considered to be an important regulator of airway inflammation in the pathogenesis of bronchial asthma, but the mechanism of ER stress involved in neutrophilic asthma remain not… read more here.
Keywords: neutrophilic asthma; stress; inflammation; atf4 chop ... See more keywords
Role of IL-22 in acute asthma mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma"
DOI: 10.1080/02770903.2022.2155186
Abstract: Abstract Introduction: Allergic asthma is often associated with eosinophilic inflammation, which is related to the T-helper cell type 2 (Th2) cytokines and responsive to corticosteroids. However, there are also phenotypes of non-Th2-mediated asthma, which have… read more here.
Keywords: ova ova; asthma; neutrophilic asthma; asthma mouse ... See more keywords
Insight into the role of mitochondrion-related gene anchor signature in mitochondrial dysfunction of neutrophilic asthma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Asthma"
DOI: 10.1080/02770903.2024.2311241
Abstract: Abstract Objective At present, targeting molecular-pharmacological therapy is still difficult in neutrophilic asthma. The investigation aims to identify and validate mitochondrion-related gene signatures for diagnosis and specific targeting therapeutics in neutrophilic asthma. Methods Bronchial biopsy… read more here.
Keywords: signature; neutrophilic asthma; gene; signature mitodegs ... See more keywords
sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma.
Sign Up to like & getrecommendations! Published in 2021 at "Immunological investigations"
DOI: 10.1080/08820139.2021.1928183
Abstract: Background: Neutrophilic asthma (NA) may result in irreversible airflow limitations. Soluble advanced glycosylation receptor (sRAGE) has been shown to be associated with neutrophilic airway inflammation. However, the association between sRAGE and mucus hypersecretion in NA… read more here.
Keywords: neutrophilic asthma; mouse model; srage; mucus hypersecretion ... See more keywords
Luteolin alleviated neutrophilic asthma by inhibiting IL-36γ secretion-mediated MAPK pathways
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2160770
Abstract: Abstract Context Luteolin can affect multiple biological functions, such as anti-inflammatory, antioxidant and immune enhancement processes. Luteolin can inhibit inflammation of T2-high asthma, but its role in neutrophilic asthma has been insufficently studied. Objective This… read more here.
Keywords: luteolin; neutrophilic asthma; secretion; mediated mapk ... See more keywords
Synergistic effect of roflumilast with dexamethasone in a neutrophilic asthma mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13635
Abstract: Asthma is a chronic airway inflammatory disease with heterogeneous features. Most cases of asthma are steroid sensitive, but 5%‐10% are unresponsive to steroids, leading to challenges in treatment. Neutrophilic asthma is steroid‐resistant and characterized by… read more here.
Keywords: asthma; rof; neutrophilic asthma; asthma mouse ... See more keywords
The onset, development and pathogenesis of severe neutrophilic asthma
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12522
Abstract: Bronchial asthma is divided into Th2 high, Th2 low and mixed types. The Th2 high type is dominated by eosinophils while the Th2 low type is divided into neutrophilic and paucigranulocytic types. Eosinophilic asthma has… read more here.
Keywords: asthma; neutrophilic asthma; severe neutrophilic; treatment neutrophilic ... See more keywords
The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis
Sign Up to like & getrecommendations! Published in 2025 at "Respiratory Research"
DOI: 10.1186/s12931-025-03313-7
Abstract: Neutrophilic asthma, characterized by the relative accumulation of neutrophils in the airways, constitutes a distinct endotype of asthma resistant to corticosteroid and associated with severe and uncontrolled cases. Milk fat globule-EGF factor 8 (MFGE8) is… read more here.
Keywords: integrin; netosis; mfge8; neutrophilic asthma ... See more keywords
Xiao Qing Long Tang ameliorates neutrophil extracellular trap-dendritic cells-T helper 17 cell axis in Neutrophilic Asthma
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DOI: 10.1371/journal.pone.0336333
Abstract: BACKGROUND Neutrophilic asthma (NA) is an allergic airway inflammation disease featuring heterogeneous neutrophil infiltration, which is driven by the interactions between dendritic cells (DCs) and T helper (Th) 17 cells. Neutrophils release neutrophil extracellular traps… read more here.
Keywords: neutrophil extracellular; ova lps; cell; neutrophilic asthma ... See more keywords
Distinct Airway Microbiome and Metabolite Profiles in Eosinophilic and Neutrophilic Asthma
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Asthma and Allergy"
DOI: 10.2147/jaa.s521800
Abstract: Background Asthma is a chronic, heterogeneous disease driven by inflammatory phenotypes, primarily eosinophilic asthma (EA) and neutrophilic asthma (NEA). While allergen triggers are well-known, the role of the airway microbiome and metabolites in asthma exacerbations… read more here.
Keywords: airway microbiome; distinct airway; external cohort; neutrophilic asthma ... See more keywords