Neutrophilic inflammation in asthma: mechanisms and therapeutic considerations
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Respiratory Medicine"
DOI: 10.1080/17476348.2017.1268919
Abstract: ABSTRACT Introduction: Neutrophilic airway inflammation represents a pathologically distinct form of asthma and frequently appears in symptomatic adulthood asthmatics. However, clinical impacts and mechanisms of the neutrophilic inflammation have not been thoroughly evaluated up to… read more here.
Keywords: mechanisms neutrophilic; inflammation; airway inflammation; neutrophilic airway ... See more keywords
Neutrophilic inflammation in chronic rhinosinusitis
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000868
Abstract: Purpose of review Over the last years, extensive research has been done on neutrophils and their contribution in chronic rhinosinusitis (CRS), and made it clear that they are more than just a bystander in this… read more here.
Keywords: inflammation chronic; crs; neutrophilic inflammation; chronic rhinosinusitis ... See more keywords
The emerging role for metabolism in fueling neutrophilic inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13157
Abstract: Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a metabolic challenge for infiltrating cells. Long believed to… read more here.
Keywords: metabolism fueling; neutrophilic inflammation; metabolism; emerging role ... See more keywords
Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID‐19 from influenza pneumonia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15179
Abstract: Infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can lead to severe pneumonia, but also thrombotic complications and non‐pulmonary organ failure. Recent studies suggest intravascular neutrophil activation and subsequent immune cell–triggered immunothrombosis as a… read more here.
Keywords: inflammation immunothrombosis; covid; pneumonia; vascular neutrophilic ... See more keywords
Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aba9301
Abstract: ACHOO!-trophils? Why some individuals come down with a cold in any given year, whereas others are spared, is poorly understood. Habibi et al. exposed volunteers to respiratory syncytial virus (RSV), one of the pathogens responsible… read more here.
Keywords: infection; exposure; respiratory; rsv infection ... See more keywords
Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.03336-20
Abstract: Pseudomonas aeruginosa pulmonary infection can lead to exaggerated neutrophilic inflammation and tissue destruction, yet host factors that regulate the neutrophilic response is not fully known. IL-36γ is a proinflammatory cytokine that dramatically increases in bioactivity… read more here.
Keywords: neutrophilic inflammation; mice; response; infection ... See more keywords
Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma.
Sign Up to like & getrecommendations! Published in 2022 at "Thorax"
DOI: 10.1136/thorax-2021-218555
Abstract: BACKGROUND Severe neutrophilic asthma is resistant to treatment with glucocorticoids. The immunomodulatory protein macrophage migration inhibitory factor (MIF) promotes neutrophil recruitment to the lung and antagonises responses to glucocorticoids. We hypothesised that MIF promotes glucocorticoid… read more here.
Keywords: inflammation; neutrophilic inflammation; glucocorticoid resistance; mif ... See more keywords
Calprotectin as a New Sensitive Marker of Neutrophilic Inflammation in Patients with Bronchiolitis Obliterans
Sign Up to like & getrecommendations! Published in 2020 at "Mediators of Inflammation"
DOI: 10.1155/2020/4641585
Abstract: Introduction Bronchiolitis obliterans (BO) is a chronic disease in which persistent inflammation leads to obstruction and obliteration of the small airways. The aim of this study was to evaluate the value of calprotectin as an… read more here.
Keywords: bronchiolitis obliterans; inflammation; lung; calprotectin ... See more keywords
Relationship between Eosinophilic and Neutrophilic Inflammation in Chinese Chronic Rhinosinusitis with Nasal Polyps.
Sign Up to like & getrecommendations! Published in 2023 at "International archives of allergy and immunology"
DOI: 10.1159/000528946
Abstract: INTRODUCTION Chronic rhinosinusitis with nasal polyps (CRSwNPs) in China is characterized by a mixed eosinophilic-neutrophilic inflammation, linking to a more heterogeneous clinical phenotype. However, the relationship between eosinophilic and neutrophilic inflammation in Chinese patients with… read more here.
Keywords: eosinophilic neutrophilic; neutrophilic inflammation; chronic rhinosinusitis; rhinosinusitis nasal ... See more keywords
Calprotectin as new sensitive marker of neutrophilic inflammation in patients with bronchiolitis obliterans
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa4649
Abstract: Introduction. Bronchiolitis obliterans (BO) is a chronic disease in which persistent inflammation leads to obstruction and obliteration of the small airways. The aim of this study was to evaluate the value of calprotectin as an… read more here.
Keywords: bronchiolitis obliterans; inflammation; lung; calprotectin ... See more keywords
Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.793073
Abstract: The mechanisms underlying neutrophilic inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) remain poorly investigated. This study aimed to examine the factors that contribute to tissue neutrophilia in CRSwNP. The numbers of neutrophils and active… read more here.
Keywords: neutrophilic inflammation; neu low; tissue; high nps ... See more keywords