Chronic neutrophilic leukemia: 2022 update on diagnosis, genomic landscape, prognosis, and management
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26481
Abstract: Chronic neutrophilic leukemia (CNL) is a rare, often aggressive myeloproliferative neoplasm (MPN) defined by persistent mature neutrophilic leukocytosis, bone marrow granulocyte hyperplasia, and frequent hepatosplenomegaly. The 2013 seminal discovery of oncogenic driver mutations in colony‐stimulating… read more here.
Keywords: leukemia 2022; chronic neutrophilic; neutrophilic leukemia; 2022 update ... See more keywords
Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-017-0413-y
Abstract: Purpose of ReviewWe reviewed recent diagnostic and therapeutic progress in chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML). We summarized recent genetic data that may guide future efforts towards implementing risk-adapted therapy based… read more here.
Keywords: neutrophilic leukemia; progress chronic; myeloid; leukemia ... See more keywords
T618I CSF3R mutations in chronic neutrophilic leukemia induce oncogenic signals through aberrant trafficking and constitutive phosphorylation of the O-glycosylated receptor form.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.030
Abstract: Activating mutations in the membrane-proximal region of the colony-stimulating factor 3 receptor (CSF3R) are a hallmark of chronic neutrophilic leukemia (CNL) with the T618I mutation being most common. The mechanisms underlying constitutive activation of the… read more here.
Keywords: receptor; t618i csf3r; neutrophilic leukemia; chronic neutrophilic ... See more keywords
Distinct clinical, laboratory and molecular features of myeloproliferative neoplasm patients with splanchnic vein thrombosis
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.14958
Abstract: Baumann, M.A., Paul, C.C., Lemley-Gillespie, S., Oyster, M. & Gomez-Cambronero, J. (2001) Modulation of MEK activity during G-CSF signalling alters proliferative versus differentiative balancing. American Journal of Hematology, 68, 99–105. Billio, A., Venturi, R., Morello,… read more here.
Keywords: hematology; polycythemia vera; neutrophilic leukemia; distinct clinical ... See more keywords
Chronic neutrophilic leukemia, an extremely rare cause of neutrophilia in childhood: Cure with hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Transplantation"
DOI: 10.1111/petr.13199
Abstract: CNL is a rare myeloproliferative disorder frequently seen in older adults. A significant proportion of patients show progression to AML. Here, we report the case of a patient with FA who was monitored for leukopenia… read more here.
Keywords: transplantation chronic; neutrophilic leukemia; cure; chronic neutrophilic ... See more keywords
Eighty-year-old man with rare chronic neutrophilic leukemia caused by CSF3R T618I mutation: A case report and review of literature
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v8.i24.6337
Abstract: BACKGROUND Chronic neutrophilic leukemia (CNL) is a rare bone marrow proliferative tumor and a heterogeneous disorder. In 2016, the World Health Organization included activating mutations in the CSF3R gene as one of the diagnostic criteria,… read more here.
Keywords: csf3r t618i; neutrophilic leukemia; year old; chronic neutrophilic ... See more keywords