Bone Marrow Failure in AML: Residual Neutrophils and Erythroblasts Are Derived By Differentiation from the AML
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-205536
Abstract: Our previous work[1] suggests AML blocks the differentiation of normal haematopoietic stem cells (HSCs) leading to marrow failure. However, many patients do not have uniform pancytopenia where all differentiated blood cells are reduced e.g. some… read more here.
Keywords: differentiation; aml clone; marrow failure; neutrophils derived ... See more keywords
Role of S100A8/A9 for Cytokine Secretion, Revealed in Neutrophils Derived from ER-Hoxb8 Progenitors
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DOI: 10.3390/ijms22168845
Abstract: S100A9, a Ca2+-binding protein, is tightly associated to neutrophil pro-inflammatory functions when forming a heterodimer with its S100A8 partner. Upon secretion into the extracellular environment, these proteins behave like damage-associated molecular pattern molecules, which actively… read more here.
Keywords: secretion; role s100a8; cytokine secretion; s100a8 cytokine ... See more keywords