Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death
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DOI: 10.1021/acs.jmedchem.9b01990
Abstract: Cytochrome P450-dependent metabolism of the anti-HIV drug nevirapine (NVP) to 12-hydroxy-NVP (12-OHNVP) has been implicated in NVP toxicities. We investigated the impact of twelfth-position trideuteration (12-D3NVP) on the hepatic metabolism of and response to NVP.… read more here.
Keywords: nevirapine; twelfth position; deuteration; formation ... See more keywords
Optimization of formulation and process variables using central composite design for the production of nevirapine spray dried solid dispersion
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DOI: 10.1080/07373937.2021.1874408
Abstract: The objective of the present investigation was to develop and optimize spray dried solid dispersion for dissolution enhancement of an anti-HIV drug, Nevirapine. The pareto chart of Plackett and Bur... read more here.
Keywords: solid dispersion; nevirapine; spray dried; dried solid ... See more keywords
TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine
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DOI: 10.1155/2020/3932715
Abstract: In the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform… read more here.
Keywords: nevirapine; graphene nanoribbons; decorated graphene; spectroscopy ... See more keywords