Ebselen oxide and derivatives are new allosteric HER2 inhibitors for HER2-positive cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13419
Abstract: Human epidermal growth factor receptor 2 (ErbB2/HER2) is a tyrosine kinase receptor that is overexpressed in 25% of primary human breast cancers, as well as in multiple other cancers. HER2-targeted therapies improved progression-free and overall… read more here.
Keywords: ebselen oxide; oxide derivatives; her2; new allosteric ... See more keywords
Theoretical Design of a New Allosteric Switch and Fluorescence Chemosensor Double Functional Devices of Aza-Crown Ether
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.6b10228
Abstract: A novel molecular device (trans-azobenzene embedded N-(11-pyrenyl methyl)aza-21-crown-7) with double functional devices was designed on the basis of theoretical calculations. Pyrenyl methyl covalently bonded to aza-21-crown-7 at the nitrogen position interacting with a series of… read more here.
Keywords: new allosteric; theoretical design; double functional; design new ... See more keywords