SYNTHESIS OF NEW 4-AMINO-SUBSTITUTED 7-IMINOPYRIDO[2,3- d ]PYRIMIDINES
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DOI: 10.1007/3600
Abstract: The reaction of 4,6-dichloropyrimidine-5-carbaldehyde with cyanomethyltriphenylphosphonium chloride gave (2 Е )-3-(4,6-dichloropyrimidin-5yl)acrylonitrile, which was further used for the preparation of 4,6-diamino-substituted pyrimidinylacrylonitrile derivatives, capable of intramolecular cyclization with the formation of new 4-amino-substituted 7-iminopyrido[2,3- d ]pyrimidines.… read more here.
Keywords: amino; new amino; synthesis new; iminopyrido pyrimidines ... See more keywords
Synthesis and pre-clinical studies of new amino-acid ester thiazolide prodrugs
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DOI: 10.1016/j.ejmech.2016.09.080
Abstract: Abstract Thiazolides are polypharmacology agents with at least three mechanisms of action against a broad spectrum of parasites, bacteria and viruses. In respiratory viruses they inhibit the replication of orthomyxoviridae and paramyxoviridae at a post-translational… read more here.
Keywords: new amino; pharmacology; ester; synthesis pre ... See more keywords
Synthesis of new α-amino nitriles with insecticidal action on Aedes aegypti (Diptera: Culicidae)
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DOI: 10.1016/j.rbe.2018.01.004
Abstract: Abstract Aedes aegypti is the principal vector of arboviral pathogens that may cause diseases as dengue fever, chikungunya and zika. The harmful environmental effects of commercial pesticides coalesced with the development of insecticide-resistant populations encourage… read more here.
Keywords: aedes aegypti; synthesis new; new amino; amino nitriles ... See more keywords
New amino group functionalized porous carbon for strong chelation ability towards toxic heavy metals
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DOI: 10.1039/d0ra05220e
Abstract: Herein, ethylenediamine functionalized porous carbon (PC-ED/1.5) was synthesized, then characterized by various methods and finally used as a functional material for Cu(II) and Pb(II) ion removal from water. XPS revealed the presence of numerous functionalities… read more here.
Keywords: functionalized porous; chelation; new amino; amino group ... See more keywords
Synthesis and anticancer assessment of some new 2-amino-3-cyanopyridine derivatives
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DOI: 10.1080/00397911.2020.1870698
Abstract: Abstract The 2-Aminonicotinonitrile derivative was reacted with different bi-functional reagents such as formamide, thiourea, acetic anhydride, and phthalic anhydride under optimized conditions to give pyrimidine, thiourea, acetamide, and isoindoline derivatives, respectively, When it was treated… read more here.
Keywords: amino; new amino; synthesis anticancer; assessment new ... See more keywords
New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase
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DOI: 10.3390/pharmaceutics14061121
Abstract: To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in vitro on the epimastigote and trypomastigote forms of Trypanosoma… read more here.
Keywords: naphthoquinone; trypanosoma cruzi; naphthoquinone derivatives; trypanothione reductase ... See more keywords