Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204006
Abstract: Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known to protect tumour cells from ferroptosis upon cysteine starvation through transamination.… read more here.
Keywords: metabolism; ferroptotic pathway; new anti; tryptophan metabolism ... See more keywords
A new anti-expertise dilemma
Sign Up to like & getrecommendations! Published in 2021 at "Synthese"
DOI: 10.1007/s11229-021-03035-5
Abstract: Instability occurs when the very fact of choosing one particular possible option rather than another affects the expected values of those possible options. In decision theory: An act is stable iff given that it is… read more here.
Keywords: instability; expertise condition; anti expertise; new anti ... See more keywords
A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.069
Abstract: The development of new chemical entities against the major diseases caused by parasites is highly desired. A library of thirty diamines analogs following a minimalist approach and supported by chemoinformatics tools have been prepared and… read more here.
Keywords: approach develop; develop new; new anti; anti apicomplexa ... See more keywords
Benzo[d]thiazole-2-carbanilides as new anti-TB chemotypes: Design, synthesis, biological evaluation, and structure-activity relationship.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.05.049
Abstract: Tuberculosis is the second leading cause of deaths worldwide. The inadequacy of existing drugs to treat TB due to developed resistance and TB-HIV synergism urges for new anti-TB drugs. Seventy-two benzo[d]thiazole-2-carbanilides have been synthesized through… read more here.
Keywords: thiazole; new anti; benzo thiazole; structure activity ... See more keywords
New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus.
Sign Up to like & getrecommendations! Published in 2019 at "Fitoterapia"
DOI: 10.1016/j.fitote.2019.04.006
Abstract: The norbisabolane-type sesquiterpenoids bearing a spiroketal functionality have been found in Phyllanthus spp. and showed anti-HBV activities. As part of an ongoing effort to search for promising anti-HBV sesquiterpenes from Phyllanthus plants, we report four… read more here.
Keywords: anti hbv; new anti; norbisabolane; norbisabolane sesquiterpenes ... See more keywords
New anti-ablation candidate for carbon/carbon composites: Preparation, composition and ablation behavior of Y2Hf2O7 coating under an oxyacetylene torch
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the European Ceramic Society"
DOI: 10.1016/j.jeurceramsoc.2018.07.042
Abstract: Abstract Y2Hf2O7 possesses low thermal conductivity and high melting point, which make it promising for a new anti-ablation material. For evaluating the thermal stability and the potential applications of Y2Hf2O7 on anti-ablation protection of C/C… read more here.
Keywords: anti ablation; carbon; y2hf2o7; ablation ... See more keywords
A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.01.009
Abstract: The majority of patients with metastatic breast cancer who are treated with the anti-HER2 monoclonal antibody, trastuzumab, generally develop resistance to the drug within a year after initiation of the treatment. Here we describe a… read more here.
Keywords: combination; pertuzumab; anti her2; antibody ... See more keywords
Briaviodiols B–E, new anti-inflammatory hydroperoxyfurancembranoids from Briareum violaceum
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.01.010
Abstract: Abstract Four new hydroperoxyfurancembranoids, briaviodiols B–E (1–4), were obtained from an octocoral identified as Briareum violaceum. The structures of cembranoids 1–4 were established by using spectroscopic methods and comparing the spectroscopic data with those of… read more here.
Keywords: new anti; briareum violaceum; briaviodiols new; anti inflammatory ... See more keywords
Characterization of a new anti-enterovirus 68 compound purified from avocado.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00404
Abstract: One of the major challenges in development of anti-enterovirus (EV) drug is in the safety of the drug. Here, we attempt to identity anti-EV compound from an edible plant extract library, and identify potent anti-enterovirus… read more here.
Keywords: anti enterovirus; new anti; compound; characterization new ... See more keywords
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis
Sign Up to like & getrecommendations! Published in 2018 at "Biofouling"
DOI: 10.1080/08927014.2018.1544246
Abstract: Abstract Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and… read more here.
Keywords: pentadecanal inspired; anti biofilm; new anti; staphylococcus epidermidis ... See more keywords
Calamusins J-K: new anti-angiogenic sesquiterpenes from Sarcophyton glaucum.
Sign Up to like & getrecommendations! Published in 2020 at "Natural product research"
DOI: 10.1080/14786419.2020.1828404
Abstract: Chemical investigation of the organic extract of the marine soft coral Sarcophyton glaucum from Red Sea, Egypt, afforded two new hydroazulenes; calamusin J (1) and its hydroperoxide derivative calamusin K (2) in addition to eight… read more here.
Keywords: sarcophyton glaucum; anti angiogenic; new anti; angiogenic sesquiterpenes ... See more keywords