Exploration of (3‐benzyl‐5‐hydroxyphenyl)carbamates as new antibacterial agents against Gram‐positive bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900294
Abstract: A series of (3‐benzyl‐5‐hydroxyphenyl)carbamates were evaluated as new antibacterial agents. Several compounds showed potent inhibitory activity against sensitive and drug‐resistant Gram‐positive bacteria. The compounds are ineffective against all tested Gram‐negative bacteria. The structure of the… read more here.
Keywords: new antibacterial; gram positive; hydroxyphenyl carbamates; positive bacteria ... See more keywords
New antibacterial-core structures based on styryl quinolinium
Sign Up to like & getrecommendations! Published in 2017 at "Food Science and Biotechnology"
DOI: 10.1007/s10068-017-0072-8
Abstract: Quaternary quinolinium salts have been widely used as alternative antimicrobial agents. In an effort to improve the current quinolinium compounds and determine the relation between antibacterial activity and substituted functional groups, 10 different styryl quinolinium… read more here.
Keywords: new antibacterial; antibacterial core; quinolinium; core structures ... See more keywords
New antibacterial and 5-lipoxygenase activities of synthetic benzyl phenyl ketones: Biological and docking studies.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.050
Abstract: We investigated twelve benzyl phenyl ketone derivatives which are synthetic precursors of isoflavonoids that are shown be good 5-hLOX inhibitors, especially those that have the catechol group, but these precursors never have been assayed as… read more here.
Keywords: benzyl phenyl; docking studies; dihydroxy methylphenyl; new antibacterial ... See more keywords
New antibacterial thiophenes from Eclipta prostrata.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104471
Abstract: Three new thiophene derivatives, ecliprostins A-C (1-3), have been isolated from the aerial parts of a Compositae medicinal plant Eclipta prostrata, and structures of them have been elucidated by comprehensive spectroscopic analyses. Both ecliprostins A… read more here.
Keywords: new antibacterial; thiophenes eclipta; eclipta prostrata; antibacterial thiophenes ... See more keywords
A new antibacterial 3,5-dimethylorsellinic acid-based meroterpene from the marine fungus Aspergillus sp. CSYZ-1.
Sign Up to like & getrecommendations! Published in 2021 at "Fitoterapia"
DOI: 10.1016/j.fitote.2021.104908
Abstract: Chemical investigation of the extracts of Aspergillus sp. CSYZ-1 resulted in the identification of compound 1, aspergillactone, a new 3,5-dimethylorsellinic acid-based meroterpenoid, together with four known metabolites (2-5). The structure and relative configuration of 1… read more here.
Keywords: new antibacterial; acid based; antibacterial dimethylorsellinic; dimethylorsellinic acid ... See more keywords
A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03231
Abstract: In this study, the novel zinc metal-organic frameworks (MOF) nanostructure has been employed, which was developed using an affordable, environmental friendly, efficient and fast method of ultrasound-assisted reverse micelle (UARM). These nanostructures were identified with… read more here.
Keywords: new antibacterial; synthesis new; mof; nanostructures based ... See more keywords
Design, synthesis, molecular docking and DFT computational insight on the structure of Piperazine sulfynol derivatives as a new antibacterial contender against superbugs MRSA
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131333
Abstract: Abstract In this investigation, a series of piperazine sulfynol derivatives 5(a-l) were synthesized and amply characterized by various spectral techniques viz, LC-MS, 1H NMR, 13C NMR, and FT-IR. The energy and other quantum chemical computations… read more here.
Keywords: antibacterial contender; piperazine sulfynol; sulfynol derivatives; new antibacterial ... See more keywords
Conglomeratin: a new antibacterial flavonol derivative from Macaranga conglomerata Brenan (Euphorbiaceae).
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2061481
Abstract: A new prenylated kaempferol, conglomeratin (1), alongside 7 known compounds including flavonoids (2 and 3), ellagic acid derivatives (4 and 5), triterpenoids (6 and 7), and a coumarin (8) were isolated from the leaves (1 - 5)… read more here.
Keywords: macaranga; new antibacterial; macaranga conglomerata; conglomeratin new ... See more keywords
Machine Learning in Antibacterial Drug Design
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.864412
Abstract: Advances in computer hardware and the availability of high-performance supercomputing platforms and parallel computing, along with artificial intelligence methods are successfully complementing traditional approaches in medicinal chemistry. In particular, machine learning is gaining importance with… read more here.
Keywords: machine; machine learning; antibacterial agents; antibacterial drug ... See more keywords
New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11020222
Abstract: New polyketide-derived oligophenalenone dimers, bacillisporins K and L (1 and 2) and xanthoradone dimer rugulosin D (3), together with four known compounds, bacillisporin B (4), macrosporusone D (5), rugulosin A and penicillide (6 and 7),… read more here.
Keywords: antibacterial secondary; metabolites marine; derived talaromyces; secondary metabolites ... See more keywords
Inhibitors of ATP Synthase as New Antibacterial Candidates
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12040650
Abstract: ATP, the power of all cellular functions, is constantly used and produced by cells. The enzyme called ATP synthase is the energy factory in all cells, which produces ATP by adding inorganic phosphate (Pi) to… read more here.
Keywords: synthase; inhibitors atp; antibacterial candidates; atp synthase ... See more keywords