The Necessity of d-Thr in the New Antibiotic Teixobactin: A Molecular Dynamics Study
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DOI: 10.1021/acs.jcim.8b00949
Abstract: Ever since the discovery of the new antibiotic teixobactin, studies of its structure-activity relationships have never ceased. Here we focus on the chirality of the threonine (Thr) residue, which belongs to the ring motif of… read more here.
Keywords: teixobactin; antibiotic teixobactin; necessity thr; new antibiotic ... See more keywords
The Burden of the Serious and Difficult-to-Treat Infections and a New Antibiotic Available: Cefiderocol
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DOI: 10.3389/fphar.2020.578823
Abstract: Background: Infection is a disease that can occur due to the entrance of a virus, bacteria, and other infectious agents. Cefiderocol is innovative cephalosporin drug that belongs to a special class of antibiotics, sideromycins, which… read more here.
Keywords: new antibiotic; gram negative; burden serious; serious difficult ... See more keywords
Mechanism-Based Approach to New Antibiotic Producers Screening among Actinomycetes in the Course of the Citizen Science Project
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DOI: 10.3390/antibiotics11091198
Abstract: Since the discovery of streptomycin, actinomycetes have been a useful source for new antibiotics, but there have been diminishing rates of new finds since the 1960s. The decreasing probability of identifying new active agents led… read more here.
Keywords: mechanism based; antibiotic producers; new antibiotic; mechanism ... See more keywords