[New antibiotics for severe infections due to multidrug-resistant pathogens : Definitive treatment and escalation].
Sign Up to like & getrecommendations! Published in 2019 at "Der Anaesthesist"
DOI: 10.1007/s00101-019-00646-z
Abstract: Multidrug-resistant pathogens often lead to treatment failure of antimicrobial regimens. After a period of imbalance between the occurrence/spread of resistance mechanisms and the development of new substances, some new substances have meanwhile been approved and… read more here.
Keywords: treatment; new substances; new antibiotics; resistant pathogens ... See more keywords
Strategies for Discovering New Antibiotics from Bacteria in the Post-Genomic Era.
Sign Up to like & getrecommendations! Published in 2020 at "Current microbiology"
DOI: 10.1007/s00284-020-02197-8
Abstract: New antibiotics are urgently required in clinical treatment and agriculture with the development of antimicrobial resistance. However, products discovered by repeating previous strategies are either not antibiotics or already known antibiotics. There is a growing… read more here.
Keywords: bacteria post; post genomic; antibiotics bacteria; new antibiotics ... See more keywords
Learnings from past failures: future routes of antimicrobial drug discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.07.017
Abstract: Despite the unprecedented unmet need to discover new antibiotics, only a few molecules have been registered for clinical use. This shortage is primarily based on the scientific failure in the postgenomic era of drug discovery.… read more here.
Keywords: new antibiotics; drug; drug discovery; past failures ... See more keywords
Time for a change in how new antibiotics are reimbursed: Development of an insurance framework for funding new antibiotics based on a policy of risk mitigation.
Sign Up to like & getrecommendations! Published in 2017 at "Health policy"
DOI: 10.1016/j.healthpol.2017.07.011
Abstract: Healthcare systems depend on the availability of new antibiotics. However, there is a lack of treatments for infections caused by multidrug resistant (MDR) pathogens and a weak development pipeline of new therapies. One core challenge… read more here.
Keywords: risk mitigation; investment; insurance; new antibiotics ... See more keywords
Protein Epitope Mimetics: From New Antibiotics to Supramolecular Synthetic Vaccines.
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.7b00129
Abstract: Protein epitope mimetics provide powerful tools to study biomolecular recognition in many areas of chemical biology. They may also provide access to new biologically active molecules and potentially to new classes of drug and vaccine… read more here.
Keywords: chemistry; new antibiotics; protein epitope; cell ... See more keywords
Exploring halophilic environments as a source of new antibiotics.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in microbiology"
DOI: 10.1080/1040841x.2023.2197491
Abstract: Microbial natural products from microbes in extreme environments, including haloarchaea, and halophilic bacteria, possess a huge capacity to produce novel antibiotics. Additionally, enhanced isolation techniques and improved tools for genomic mining have expanded the efficiencies… read more here.
Keywords: exploring halophilic; review; new antibiotics; source new ... See more keywords
Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2022.2078308
Abstract: ABSTRACT Introduction Antibiotic resistance is one of the biggest public health threats worldwide. Currently, antibiotic-resistant bacteria kill 700,000 people every year. These data represent the near future in which we find ourselves, a ‘post-antibiotic era’… read more here.
Keywords: development new; development; treatment options; new antibiotics ... See more keywords
Studying new antibiotics for multidrug resistant infections: are today’s patients paying for unproved future benefits?
Sign Up to like & getrecommendations! Published in 2018 at "British Medical Journal"
DOI: 10.1136/bmj.k587
Abstract: Current approaches to testing new treatments for multidrug resistant bacterial diseases raise scientific and ethical issues for current and future patients, say John Powers and colleagues read more here.
Keywords: antibiotics multidrug; new antibiotics; resistant infections; studying new ... See more keywords
Using Fragment-Based Approaches to Discover New Antibiotics
Sign Up to like & getrecommendations! Published in 2018 at "Slas Discovery"
DOI: 10.1177/2472555218773034
Abstract: Fragment-based lead discovery has emerged over the past two decades as a successful approach to generate novel lead candidates in drug discovery programs. The two main advantages over conventional high-throughput screening (HTS) are more efficient… read more here.
Keywords: based approaches; new antibiotics; lead discovery; fragment based ... See more keywords
Carbapenem-Resistant Klebsiella pneumoniae Among Patients with Ventilator-Associated Pneumonia: Evaluation of Antibiotic Combinations and Susceptibility to New Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s371248
Abstract: Background Carbapenemase-producing Gram-negative bacteria, particularly Klebsiella pneumoniae (K. pneumoniae), are at the forefront of the list of causative agents of ventilator-associated pneumonia (VAP). The treatment options for such infections are limited, and various antimicrobial combinations… read more here.
Keywords: carbapenem resistant; pneumoniae; klebsiella pneumoniae; ventilator associated ... See more keywords
What to Do with the New Antibiotics?
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12040654
Abstract: Multidrug-resistant Gram-negative bacteria-related infections have become a real public health problem and have exposed the risk of a therapeutic impasse. In recent years, many new antibiotics have been introduced to enrich the therapeutic armamentarium. Among… read more here.
Keywords: antibiotics new; new antibiotics; multidrug resistant; resistant gram ... See more keywords