A New Anticancer Bisflavan-3-Ol from Boerhavia elegans
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-020-02995-3
Abstract: A new a bisflavan-3-ol, boerhavianane (1), was isolated from Boerhavia elegans L. The structure of the flavanol dimer was elucidated by detailed spectroscopic analysis including 1H, 13C NMR, COSY, HMQC, HMBC, and ESI-MS. Boerhavianane (1)… read more here.
Keywords: new anticancer; anticancer bisflavan; bisflavan; bisflavan boerhavia ... See more keywords
Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172825
Abstract: Chemotherapy plays an essential role in the management of cancer worldwide. However, it is a non-specific treatment limited by major drawbacks, thus identification and testing of new promising molecular structures representing potential drug candidates are… read more here.
Keywords: mechanism; drug candidates; new anticancer; ferrocenes new ... See more keywords
Lipophilicity of New Anticancer 1,6- and 3,6-diazaphenothiazines by of Use RP TLC and Different Computational Methods.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmy006
Abstract: The lipophilicity of new two series of anticancer active 10-substituted 1,6- and 3,6-diazaphenothiazines has been investigated using reversed-phase thin-layer chromatography. Their lipophilicity (RM0 and log PTLC) was determined with mixtures of acetone and Tris buffer… read more here.
Keywords: anticancer diazaphenothiazines; diazaphenothiazines use; lipophilicity new; lipophilicity ... See more keywords
A detailed analysis of expedited regulatory review time of marketing authorization applications for new anticancer drugs in the US and EU
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13308
Abstract: The aim of this study was to assess the effect of expedited regulatory approval programs used by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), type of product (small molecule… read more here.
Keywords: anticancer drugs; review time; review; expedited regulatory ... See more keywords
Synthesis of new anticancer and anti‐inflammatory isoxazolines and aziridines from the natural (‐)‐deltoin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13013
Abstract: This work describes the synthesis, the bioactivity and the structure–activity relationship of new derivatives from a natural coumarin. read more here.
Keywords: anti inflammatory; synthesis new; anticancer anti; inflammatory isoxazolines ... See more keywords
A New Anticancer Semisynthetic Theobromine Derivative Targeting EGFR Protein: CADDD Study
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13010191
Abstract: A new lead compound has been designed as an antiangiogenic EGFR inhibitor that has the pharmacophoric characteristics to bind with the catalytic pocket of EGFR protein. The designed lead compound is a (para-chloro)acetamide derivative of… read more here.
Keywords: egfr protein; new anticancer; protein; semisynthetic theobromine ... See more keywords
How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs
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DOI: 10.3390/molecules25071756
Abstract: The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD)… read more here.
Keywords: development new; chemistry; new anticancer; drug ... See more keywords
Lipophilicity and Pharmacokinetic Properties of New Anticancer Dipyridothiazine with 1,2,3-Triazole Substituents
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041253
Abstract: The lipophilicity parameters (logPcalcd, RM0 and logPTLC) of 10 new active anticancer dipirydothiazines with a 1,2,3-triazole ring were determined theoretically using computational methods and experimentally by reversed-phase TLC. Experimental lipophilicity was assessed using mobile phases… read more here.
Keywords: properties new; pharmacokinetic properties; lipophilicity; anticancer dipyridothiazine ... See more keywords
Discovery of Leptulipin, a New Anticancer Protein from theIranian Scorpion, Hemiscorpius lepturus
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072056
Abstract: Cancer is one of the leading causes of mortality in the world. Unfortunately, the present anticancer chemotherapeutics display high cytotoxicity. Accordingly, the discovery of new anticancer agents with lower side effects is highly necessitated. This… read more here.
Keywords: cell; hemiscorpius lepturus; scorpion; anticancer ... See more keywords