New antifungal tetrahydrofuran derivatives from a marine sponge-associated fungus Aspergillus sp. LS78.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104677
Abstract: Two new tetrahydrofuran derivatives named aspericacids A and B (1 and 2) were isolated from the metabolites produced by the sponge-associated Aspergillus sp. LS78. They represented an unusual type of tetrahydrofuran derivatives, possessing 2,5-disubstituted tetrahydrofuran… read more here.
Keywords: new antifungal; tetrahydrofuran; aspergillus ls78; tetrahydrofuran derivatives ... See more keywords
Insights on the anticandidal activity of non-antifungal drugs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2019.07.004
Abstract: The search for new antifungal strategies to overcome Candida infections is essential and a matter of public health, due to the high mortality associated to candidiasis, the increasing incidence of resistance to antifungals and the… read more here.
Keywords: new antifungal; non antifungal; antifungal drugs; drug ... See more keywords
A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2017.1338287
Abstract: Abstract A new bibenzyl derivative (4), together with two glycosylated flavonoids (1 and 2), batatasin III (3) and the phenanthrene isohircinol (5) were isolated from the aerial parts of Gavilea lutea. Their structures were elucidated… read more here.
Keywords: antifungal antiprotozoal; new antifungal; gavilea lutea; bibenzyl derivative ... See more keywords
Novel avenues for identification of new antifungal drugs and current challenges
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2097659
Abstract: ABSTRACT Introduction Some of the fungi have become pathogenic to humans, and these opportunistic pathogens are able to cause severe systemic mycoses. Areas covered The number of antifungals for systemic administration is limited and resistance… read more here.
Keywords: drugs current; identification new; antifungal drugs; new antifungal ... See more keywords
Conventional therapy and new antifungal drugs against Malassezia infections.
Sign Up to like & getrecommendations! Published in 2020 at "Medical mycology"
DOI: 10.1093/mmy/myaa087
Abstract: Malassezia yeasts are commensal microorganisms occurring on the skin of humans and animals causing dermatological disorders or systemic infections in severely immunocompromised hosts. Despite attempts to control such yeast infections with topical and systemic antifungals,… read more here.
Keywords: new antifungal; conventional therapy; antifungal drugs; therapy new ... See more keywords
Advances in fungal chemical genomics for the discovery of new antifungal agents
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14484
Abstract: Invasive fungal infections have escalated from a rare curiosity to a major cause of human mortality around the globe. This is in part due to a scarcity in the number of antifungal drugs available to… read more here.
Keywords: fungal chemical; new antifungal; discovery new; chemical genomics ... See more keywords
Looking for new antifungal drugs from flavonoids: impact of the genetic diversity of Candida albicans on the in-vitro response.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666171226102700
Abstract: In an era in which antimicrobial resistance is increasing at an alarming pace, it's very important to find new antimicrobial agents effective against pathogenic microrganisms resistant to traditional treatments. Among the notable breakthroughs in the… read more here.
Keywords: looking new; genetic diversity; new antifungal; candida albicans ... See more keywords
What do we have new in antifungal peptides? A patent review.
Sign Up to like & getrecommendations! Published in 2022 at "Future microbiology"
DOI: 10.2217/fmb-2022-0105
Abstract: Drugs used to fight fungal infections may cause toxic or adverse drug interactions. For this reason, there is an increase in the development of natural, semisynthetic and synthetic antifungal peptides. This study aimed to perform… read more here.
Keywords: patent review; peptides patent; antifungal peptides; new antifungal ... See more keywords
Sulfur Metabolism as a Promising Source of New Antifungal Targets
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8030295
Abstract: Fungal infections are a growing threat to human health. Despite their clinical relevance, there is a surprisingly limited availability of clinically approved antifungal agents, which is seriously aggravated by the recent appearance and fast spread… read more here.
Keywords: metabolism; sulfur metabolism; promising source; new antifungal ... See more keywords
Pharmacodynamics, Mechanisms of Action and Resistance, and Spectrum of Activity of New Antifungal Agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8080857
Abstract: Several new antifungals are currently in late-stage development, including those with novel pharmacodynamics/mechanisms of action that represent new antifungal classes (manogepix, olorofim, ATI-2307, GR-2397). Others include new agents within established classes or with mechanisms of… read more here.
Keywords: action; activity; resistance; new antifungal ... See more keywords
New Antifungal Agents with Azole Moieties
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15111427
Abstract: Fungal conditions affect a multitude of people worldwide, leading to increased hospitalization and mortality rates, and the need for novel antifungals is emerging with the rise of resistance and immunocompromised patients. Continuous use of azole… read more here.
Keywords: agents azole; activity; new antifungal; azole moieties ... See more keywords