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   Articles with "new antimalarial" as a keyword



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Targeting malaria protein kinases.

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recommendations! Published in 2021 at "Advances in protein chemistry and structural biology"

DOI: 10.1016/bs.apcsb.2020.10.004

Abstract: Malaria is one of the most impacting public health problems in tropical and subtropical areas of the globe, with approximately 200 million cases worldwide annually. In the absence of an effective vaccine, rapid treatment is… read more here.

Keywords: new antimalarial; protein kinases; malaria protein; biology ... See more keywords
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Artesunate, a new antimalarial clinical drug, exhibits potent anti‐AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways

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recommendations! Published in 2022 at "British Journal of Pharmacology"

DOI: 10.1111/bph.15986

Abstract: Artesunate, approved by the Food and Drug Administration in 2020 as a new treatment for severe malaria, also shows anti‐tumour activity against acute myeloid leukaemia (AML). However, the underlying molecular mechanism(s) of artesunate‐induced apoptosis and… read more here.

Keywords: antimalarial clinical; aml; artesunate new; activity ... See more keywords
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High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death

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recommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00352-17

Abstract: ABSTRACT Albitiazolium is the lead compound of bisthiazolium choline analogues and exerts powerful in vitro and in vivo antimalarial activities. Here we provide new insight into the fate of albitiazolium in vivo in mice and… read more here.

Keywords: albitiazolium lead; accumulation; new antimalarial; albitiazolium ... See more keywords
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Synthesis and characterisation of new antimalarial fluorinated triazolopyrazine compounds

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recommendations! Published in 2023 at "Beilstein Journal of Organic Chemistry"

DOI: 10.3762/bjoc.19.11

Abstract: Nine new fluorinated analogues were synthesised by late-stage functionalisation using Diversinate™ chemistry on the Open Source Malaria (OSM) triazolopyrazine scaffold (Series 4). The structures of all analogues were fully characterised by NMR, UV and MS… read more here.

Keywords: triazolopyrazine; characterisation new; chemistry; synthesis characterisation ... See more keywords