Synthesis and Evaluation of a Series of New Bulleyaconitine A Derivatives as Analgesics
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02944
Abstract: As a nonaddictive analgesic widely used in clinics, the LD50 of bulleyaconitine A is just only 0.92 mg/kg, which exhibits obvious toxicity. Therefore, 31 new non-natural C19-diterpenoid alkaloids (2a–w, 2′a–e, 3, 4a, and 4b) were… read more here.
Keywords: derivatives analgesics; new bulleyaconitine; bulleyaconitine derivatives; evaluation series ... See more keywords