Drug upgrade: A complete methodology from old drug to new chemical entities using Nematic Protein Organization Technique
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.22151
Abstract: Drug repurposing is used to propose new therapeutic perspectives. Here, we introduce “Drug Upgrade”, that is, characterizing the mode of action of an old drug to generate new chemical entities and new therapeutics. We proposed… read more here.
Keywords: methodology; hcq; old drug; drug ... See more keywords
New Chemical Transformations Involving SO2 F2 -Mediated Alcohol Activation.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical record"
DOI: 10.1002/tcr.202300107
Abstract: Sulfuryl fluoride is a gas produced on a multi-ton scale for its use as a fumigant. In the last decades, it has gained interest in organic synthesis as a reagent with unique properties in terms… read more here.
Keywords: sulfuryl fluoride; so2 mediated; transformations involving; chemical transformations ... See more keywords
Prospective computational design and in vitro bio-analytical tests of new chemical entities as potential selective CYP17A1 lyase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103462
Abstract: The development and advancement of prostate cancer (PCa) into stage 4, where it metastasize, is a major problem mostly in elder males. The growth of PCa cells is stirred up by androgens and androgen receptor… read more here.
Keywords: new chemical; selective cyp17a1; prospective computational; chemical entities ... See more keywords
New chemical data on the ant Myrmecina graminicola (Formicidae, Myrmicinae): Unusual abundance of alkene hydrocarbons and esters
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Systematics and Ecology"
DOI: 10.1016/j.bse.2018.06.004
Abstract: Abstract We investigated the possible origin of the specific odor of the terricolous ant Myrmecina graminicola by elucidating its pattern of volatiles. It appeared to have a very large hypertrophied poison gland reservoir, which contains… read more here.
Keywords: myrmecina graminicola; new chemical; ant myrmecina; chemical data ... See more keywords
Three new chemical constituents of Korthalsella japonica
Sign Up to like & getrecommendations! Published in 2018 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2017.12.003
Abstract: Abstract The mistletoe Korthalsella japonica is used in traditional Chinese medicine to treat injury and to enhance blood circulation. Phytochemical constituents of this plant are not as well known as those of other species. In… read more here.
Keywords: new chemical; korthalsella japonica; three new; constituents korthalsella ... See more keywords
Evaluation of a New Chemical Label BASA: A Comparison with Gold Standards.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c00096
Abstract: Personalized medicine involves tailoring medical treatments to the unique characteristics of each individual. For example, genomic insights enable precise diagnoses and targeted therapies in oncology. However, significant challenges remain in understanding the molecular mechanisms underlying… read more here.
Keywords: evaluation new; chemical label; medicine; new chemical ... See more keywords
Advancing New Chemical Modalities into Clinical Studies.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00375
Abstract: Drug discovery and development has experienced an incredible paradigm shift in the past two decades. What once was considered a predominant R&D landscape of small molecules within a prescribed properties and mechanism space now includes… read more here.
Keywords: clinical studies; advancing new; modalities clinical; chemical modalities ... See more keywords
New Chemical Modalities and Strategic Thinking in Early Drug Discovery.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00582
Abstract: The classical toolbox for drug discovery is continuously expanding beyond traditional small molecules. New chemical modalities including RNA therapeutics, protein degraders, cyclopeptides, antibody drug conjugates, and gene therapy have matured, demonstrating clinical success and are… read more here.
Keywords: new chemical; modalities strategic; drug; chemical modalities ... See more keywords
A new chemical approach for proximity labelling of chromatin-associated RNAs and proteins with visible light irradiation.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc06251c
Abstract: A new nucleus-localized singlet oxygen generator was designed and synthesized. Its capability to label nucleus-localized biomolecules through spatially-restricted oxidation under visible light was validated using fluorescence confocal microscopy. Western blot and RT-qPCR were performed to… read more here.
Keywords: new chemical; visible light; chromatin associated; associated rnas ... See more keywords
Assessing Micronutrients in Soil with a New Chemical Extractant Using Isotopic Dilution Techniques: Linkages to Labile Fractions in Soil
Sign Up to like & getrecommendations! Published in 2024 at "Communications in Soil Science and Plant Analysis"
DOI: 10.1080/00103624.2024.2377624
Abstract: ABSTRACT With the purpose of economizing the routine soil testing for micronutrients and avoiding the use of multiple soil extraction procedures, a laboratory investigation was attempted to evaluate a new chemical extractant for assessing the… read more here.
Keywords: mes vera; soil; chemical extractant; isotopic dilution ... See more keywords
New chemical constituent from the stem of Cuscuta reflexa Roxb. and its biological activities
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1669033
Abstract: Abstract Chemical investigations on the stem of Cuscuta reflexa Roxb. (Convolvulaceae) led to the isolation of one new compound characterised as 3′,4′-dimethoxy-1-phenyl-1α, 2-ethanediol (1), along with eight known compounds as tridecanyl palmitate, palmitic acid, n-pentatriacontane,… read more here.
Keywords: new chemical; chemical constituent; cuscuta reflexa; reflexa roxb ... See more keywords