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Published in 2018 at "Journal of Food Measurement and Characterization"
DOI: 10.1007/s11694-018-9793-5
Abstract: Chemical composition of essential oil (EO) obtained by hydrodistillation of the aerial parts of Achillea santolina L. was analysed using GC and GC–MS. Especially, this study involved a large scale investigation, using different regions in…
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Keywords:
essential oil;
new chemotype;
achillea santolina;
different regions ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.011
Abstract: The enzyme Δ24-dehydrocholesterol reductase (DHCR24) catalyzes the reduction of the Δ24-double bond in the side chain of cholesterol precursors. Recent biochemical investigations fuel the hope that inhibition of DHCR24, resulting in an accumulation of desmosterol,…
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Keywords:
new chemotype;
selective potent;
dehydrocholesterol reductase;
dhcr24 ... See more keywords
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Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00534
Abstract: Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR…
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Keywords:
fxr;
fxr antagonists;
discovery new;
oxadiazole core ... See more keywords