Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100029
Abstract: New coumarin derivatives 9a–f, 10a–e, and 11a–f were synthesized and evaluated for their cytotoxic activity against a human breast cancer cell line (MCF‐7). All compounds exhibited good activity in the nanomolar range, using doxorubicin and… read more here.
Keywords: new coumarin; biological evaluation; evaluation new; coumarin derivatives ... See more keywords
Fluorescence quenching study of new coumarin-derived fluorescent imidazole-based chemosensor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.114316
Abstract: Abstract In this study, we report a new coumarin-based fluorescent sensor (CUM-P10) for sensitive detection of different inorganic quenchers (halide ions, aromatic amines or transition metal ions). The CUM-P10 copolymer was obtained through a post-synthesis… read more here.
Keywords: cum p10; fluorescence quenching; new coumarin; fluorescence ... See more keywords
Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2018.1530399
Abstract: Abstract Cytochrome P450 (CYP) enzymes constitute an essential xenobiotic metabolizing system that regulates the elimination of lipophilic compounds from the body. Convenient and affordable assays for CYP enzymes are important for assessing these metabolic pathways.… read more here.
Keywords: new coumarin; development new; coumarin; coumarin derivatives ... See more keywords
Synthesis and electroluminescent properties of new coumarin derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Crystals and Liquid Crystals"
DOI: 10.1080/09273948.2017.1338882
Abstract: ABSTRACT 4-methyl-7-(10-(pyren-1-yl)anthracen-9-yl)-2H-chromen-2-one (PAC), 7,7'-(anthracene-9,10-diyl)bis(4- methyl-2H-chromen-2-one) (CAC), 7-Ant-hracen-9-yl-4-methyl-chromen-2-one (AC), and 7-(naphthalen-1-yl)-2H-chromen-2-one (NC) were synthesized through Suzuki aryl-aryl coupling reaction. Optical and electroluminescence (EL) properties were evaluated by UV-visible absorption, photoluminescence (PL) spectra, and EL devices. Synthesized… read more here.
Keywords: synthesis electroluminescent; new coumarin; electroluminescent properties; chromen one ... See more keywords
A new coumarin from Murraya alata activates TRPV1 channel
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1548455
Abstract: Abstract One new coumarin, muralatin R, was isolated from the leaves of Murraya alata Drake (Rutaceae). Its structure was elucidated by extensive analysis of the NMR and MS data, along with the specific rotation comparison.… read more here.
Keywords: new coumarin; coumarin murraya; trpv1 channel; alata activates ... See more keywords
New coumarin from the roots of Prangos pabularia growing wild in Tajikistan.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2102627
Abstract: Dichloromethane and butanol extracts of the roots of Prangos pabularia were analyzed to determine chemical constituents and biological activity. The new coumarin 1, yuganin B ((5-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-((2-oxo-2H-chromen-7-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-3,4-dihydroxytetrahydrofuran-3-yl)methyl 4-hydroxy-3-methoxybenzoate) along with three phenolic and twenty-four known coumarins… read more here.
Keywords: prangos pabularia; coumarin roots; growing wild; roots prangos ... See more keywords
8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902019000317609
Abstract: This work was conducted with funding from Universidad Nacional de Colombia, Bogota (VRI/DIB, Project: 13668) read more here.
Keywords: new coumarin; coumarin monoamine; propyl dioxolo; dioxolo chromen ... See more keywords
Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2021.762248
Abstract: A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation… read more here.
Keywords: synthesis; new coumarin; three component; component synthesis ... See more keywords
Six New Coumarin Glycosides from the Aerial Parts of Gendarussa vulgaris
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24081456
Abstract: Six new coumarin glycosides, genglycoside A–F (1–6), were isolated from the aerial parts of Gendarussa vulgaris, along with ten known analogues (7–16). Their structures were unambiguously established on the basis of extensive spectroscopic data and… read more here.
Keywords: new coumarin; gendarussa vulgaris; coumarin glycosides; parts gendarussa ... See more keywords
New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26113254
Abstract: In the last years, the connection between the endocannabinoid system (eCS) and neuroprotection has been discovered, and evidence indicates that eCS signaling is involved in the regulation of cognitive processes and in the pathophysiology of… read more here.
Keywords: new coumarin; cholinergic cannabinoid; system; derivatives cholinergic ... See more keywords
5-Demethoxy-10′-ethoxyexotimarin F, a New Coumarin with MAO-B Inhibitory Potential from Murraya exotica L.
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154950
Abstract: Rutaceae plants are known for being a rich source of coumarins. Preliminary molecular docking showed that there was no significant difference for coumarins in Clausena and Murraya, both of which had high scoring values and… read more here.
Keywords: murraya exotica; mao; demethoxy ethoxyexotimarin; ethoxyexotimarin new ... See more keywords