Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones
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DOI: 10.1021/acsmedchemlett.1c00539
Abstract: Venezuelan and eastern equine encephalitis viruses are disease-causing, neuropathic pathogens with no approved treatment options in humans. While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone rearrangement, we discovered that diamine-treated, 2-dihalomethylquinolinones… read more here.
Keywords: inhibitors via; alphavirus inhibitors; encephalitic alphavirus; piperazinobenzodiazepinones new ... See more keywords