New 1H‐indole‐2,3‐dione 3‐thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors
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DOI: 10.1002/ardp.202200023
Abstract: 1‐Methyl/ethyl/benzyl‐5‐(un)substituted 1H‐indole‐2,3‐diones (2, 3, and 4) were synthesized by reaction of 5‐(un)substituted 1H‐indole‐2,3‐diones (1) with methyl iodide, ethyl chloride, and benzyl bromide. (3‐Sulfamoylphenyl)isothiocyanate (6) was obtained by the treatment of 3‐aminobenzenesulfonamide (5) with thiophosgene. Compound… read more here.
Keywords: substituted indole; thiosemicarbazones sulfamoylphenyl; new indole; dione ... See more keywords
New indole and indazole derivatives as potential antimycobacterial agents
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DOI: 10.1007/s00044-019-02293-w
Abstract: AbstractThe study reports on the synthesis and in vitro assessment of the antimycobacterial activity of a series of new indole- and indazole-based aroylhydrazones evaluated against Mycobacterium tuberculosis H37Rv. Isoniazide and ethambutol were used as reference… read more here.
Keywords: indole indazole; antimycobacterial activity; new indole; indazole derivatives ... See more keywords
New indole based hybrid oxadiazole scaffolds with N-substituted acetamides: As potent anti-diabetic agents.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.08.010
Abstract: Current study is based on the sequential conversion of indolyl butanoic acid (1) into ethyl indolyl butanoate (2), indolyl butanohydrazide (3), and 1,3,4-oxadiazole-2-thiol analogs (4) by adopting chemical transformations. In a parallel series of reactions,… read more here.
Keywords: oxadiazole scaffolds; hybrid oxadiazole; scaffolds substituted; based hybrid ... See more keywords
New indole alkaloids from the seeds of Datura metel L.
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DOI: 10.1016/j.fitote.2020.104726
Abstract: Four new indole alkaloids, daturametelindoles A-D (1-4) were isolated from the EtOAc soluble partition of the ethanol extract of the Datura metel seeds. The structures of the new compounds were determined based on spectroscopic evidence,… read more here.
Keywords: datura metel; seeds datura; indole alkaloids; alkaloids seeds ... See more keywords
A new indole alkaloid from the traditional Chinese medicine Chansu
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2017.1339697
Abstract: Abstract A new indole alkaloid N′-formylserotonin (1), along with five known indole alkaloids N′-methylserotonin (2), 5-hydroxy-1H-indole-3-carbaldehyde (3), N-acetylserotonin (4), 6-hydroxy-1-oxo-3,4-dihydro-β-carboline (5), and bufoserotoin C (6), were isolated from the water extract of traditional Chinese medicine… read more here.
Keywords: medicine; traditional chinese; chinese medicine; new indole ... See more keywords
A new indole alkaloid from Cimicifuga heracleifolia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2018.1509855
Abstract: Abstract A new alkaloid, (E)-3-(3-methyl-1-oxo-2-butenyl)-6-methoxy-1 H -indole (1), along with two known ones, was isolated from the aerial parts of Cimicifuga heracleifolia. The structure of 1 was elucidated on the basis of extensive spectroscopic data… read more here.
Keywords: alkaloid; cimicifuga heracleifolia; alkaloid cimicifuga; new indole ... See more keywords
A new indole alkaloid, antioxidant and antibacterial activities of crude extracts from Saccocalyx satureioides
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1519817
Abstract: Abstract The new acylated indole alkaloid glucoside indole-3-carboxylic acid-(6'-O-caffeoyl)-β-D-glucoside 1 has been isolated from the ethyl acetate (EtOAC) extract of Saccocalyx satureioides Coss. & Dur. (Lamiaceae) together with eight known secondary metabolites 2-9. Two indoles… read more here.
Keywords: alkaloid antioxidant; saccocalyx satureioides; antioxidant antibacterial; antibacterial activities ... See more keywords
Four new indole alkaloids from the roots of Isatis tinctoria.
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DOI: 10.1080/14786419.2020.1779716
Abstract: Chemical fractionation of the ethanolic extract of the roots of Isatis tinctoria L. (I. tinctoria) yielded fourteen indole alkaloids including four new ones, isatisindigoticanine L-N and isatindigoside M. Their structures were established on the basis… read more here.
Keywords: roots isatis; alkaloids roots; four new; indole alkaloids ... See more keywords
7-Methoxy-13-dehydroxypaxilline: New indole diterpenoid from an endophytic fungus Penicillium sp. Nb 19.
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DOI: 10.1080/14786419.2022.2107639
Abstract: ABSTACTA chemical investigation of the endophyte Penicillium sp. Nb 19, isolated from leaves of the traditionally medical plant Baphicacanthus cusia (Nees) Bremek., yielded one new indole diterpenoid, 7-methoxy-13-dehydroxypaxilline (1) together with seven known metabolites (2-8).… read more here.
Keywords: methoxy dehydroxypaxilline; dehydroxypaxilline new; new indole; penicillium ... See more keywords
Synthesis and Anticancer Evaluation of New Indole-Based Tyrphostin Derivatives and Their (p-Cymene)dichloridoruthenium(II) Complexes
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DOI: 10.3390/ijms24010854
Abstract: New N-alkylindole-substituted 2-(pyrid-3-yl)-acrylonitriles with putative kinase inhibitory activity and their (p-cymene)Ru(II) piano-stool complexes were prepared and tested for their antiproliferative efficacy in various cancer models. Some of the indole-based derivatives inhibited tumor cell proliferation at… read more here.
Keywords: evaluation new; synthesis anticancer; new indole; anticancer evaluation ... See more keywords
Paspalines C–D and Paxillines B–D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69
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DOI: 10.3390/md20110684
Abstract: Five new indole diterpenoids named paspaline C–D (1–2) and paxilline B–D (3–5), as well as eleven known analogues (6–16), were identified from fungus Penicillium brefeldianum strain WZW-F-69, which was isolated from an abalone aquaculture base… read more here.
Keywords: indole diterpenoids; wzw; new indole; penicillium brefeldianum ... See more keywords