New labdane diterpenoids from Alpinia galanga: A new type of GLP‐1 secretagogues targeting the PKA‐CREB and PI3K‐Akt signaling axes
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DOI: 10.1002/ardp.202400383
Abstract: Glucagon‐like peptide‐1 (GLP‐1) secretagogues are fascinating pharmacotherapies to overcome the defects of GLP‐1 analogs and dipeptidyl peptidase‐4 (DPP‐4) inhibitors in treating diabetes and obesity. To discover new GLP‐1 secretagogues from natural sources, alpigalangols A‐Q (1–17),… read more here.
Keywords: glp secretagogues; alpinia galanga; new labdane; labdane ... See more keywords
A new labdane diterpenoid, in vitro and in silico cytotoxicity, and protease inhibitory effects of phytochemicals from Juniperus polycarposK. Koch leaves
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DOI: 10.1080/14786419.2024.2323542
Abstract: Abstract Cytotoxicity-guided purification of Juniperus polycarpos K. Koch leaves (Cupressaceae) led to the isolation of a new labdane diterpenoid, 3-(acetyloxy)-acetylisocupressic acid (1), together with isocupressic acid (2), 3,4-dimethoxycinnamoyl alcohol (3) and deoxypodophyllotoxin (4). The chemical… read more here.
Keywords: labdane diterpenoid; cytotoxicity; koch leaves; new labdane ... See more keywords