Design, Synthesis, and Evaluation of New Mesenchymal–Epithelial Transition Factor (c-Met) Kinase Inhibitors with Dual Chiral Centers
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DOI: 10.3390/molecules27175359
Abstract: A series of tepotinib derivatives with two chiral centers was designed, synthesized, and evaluated as anticancer agents. The optimal compound (R, S)-12a strongly exhibited antiproliferative activity against MHCC97H cell lines with an IC50 value of… read more here.
Keywords: design synthesis; evaluation new; new mesenchymal; compound 12a ... See more keywords