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Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1655018
Abstract: Abstract Cunninghamella blakesleeana-mediated biotransformation of an oral contraceptive drug, levonorgestrel (1), yielded a new metabolite, 13β-ethyl-17α-ethynyl-10,17β-dihydroxy-4,6-dien-3-one (2), and two known metabolites 3 (13β-ethyl-17α-ethynyl-10β,17β-dihydroxy-4-en-3-one), and 4 (13β-ethyl-17α-ethynyl-6β,17β-dihydroxy-4-en-3-one) at an ambient temperature using aqueous media. Hydroxylation and…
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Keywords:
blakesleeana mediated;
cunninghamella blakesleeana;
new metabolite;
biotransformation oral ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030763
Abstract: In this study, the phase I hepatic metabolism pathway of a cardiovascular drug nebivolol was proposed on the basis of a human liver microsomes assay with the use of LC-HR-MS coupled with the chemometric method.…
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Keywords:
using liquid;
metabolite nebivolol;
new metabolite;
identification new ... See more keywords