Identification and characterization of citalopram new metabolites with the use of UHPLC-Q-TOF technique: In silico toxicity assessment of the identified transformation products.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113299
Abstract: In this study the metabolite profiling of citalopram with the use of human liver microsomes as well as the complementary photocatalytic method were established. This strategy allowed the detection of five metabolites of citalopram including… read more here.
Keywords: citalopram new; toxicity; characterization citalopram; new metabolites ... See more keywords
New metabolites with cytotoxic and antiproliferative activities isolated from Bonellia macrocarpa
Sign Up to like & getrecommendations! Published in 2017 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2016.12.016
Abstract: Five compounds were isolated from Bonellia macrocarpa roots: 1,3,5,6-tetramethoxy-8-methylnaphthalene (1), 3,5-dihydroxy-1,2,2-trimethyl-benzocyclobutane (2), 3-methoxy-5-octylphenol (3), 3-methoxy-2-methyl-5-pentylphenol (4), and protoprimulagenin A (5), being 1–3 new. Compound 5 showed the best effect, exhibiting cytotoxic activity on three of… read more here.
Keywords: cell lines; bonellia macrocarpa; cytotoxic antiproliferative; isolated bonellia ... See more keywords
New Metabolites from Penicillium Thymicola IBT 5891
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DOI: 10.3184/174751917x14858862342188
Abstract: Two new secondary metabolites, fumiquinazoline T and thymipyrone A, were obtained from the culture broth of marine-derived Penicillium thymicola IBT 5891. The known compounds, fumiquinazoline F and J, alantrypinone and pestafolide A, were also isolated… read more here.
Keywords: ibt 5891; thymicola ibt; penicillium thymicola; new metabolites ... See more keywords
New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon
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DOI: 10.3390/md20030186
Abstract: The biological screening of 44 marine sponge extracts for the research of bioactive molecules, with potential application in the treatment of age-related diseases (cancer and Alzheimer’s disease) and skin aging, resulted in the selection of… read more here.
Keywords: scopalina hapalia; new metabolites; metabolites marine; scopalina ... See more keywords
A Comprehensive In Silico Study of New Metabolites from Heteroxenia fuscescens with SARS-CoV-2 Inhibitory Activity
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27217369
Abstract: Chemical investigation of the total extract of the Egyptian soft coral Heteroxenia fuscescens, led to the isolation of eight compounds, including two new metabolites, sesquiterpene fusceterpene A (1) and a sterol fuscesterol A (4), along… read more here.
Keywords: comprehensive silico; silico study; new metabolites; heteroxenia fuscescens ... See more keywords