New therapeutic options for patients with heart failure with reduced ejection fraction and acute decompensated heart failure.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2022.01.003
Abstract: BACKGROUND Patients with acute decompensated heart failure (ADHF) are at severe risk of death and rehospitalization. Several clinical studies have been designed to evaluate the efficacy and safety of new molecules administered before discharge or… read more here.
Keywords: acute decompensated; heart; heart failure; decompensated heart ... See more keywords
Prediction Accuracy of Production ADMET Models as a Function of Version: Activity Cliffs Rule
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00699
Abstract: As with many other institutions, our company maintains many quantitative structure-activity relationship (QSAR) models of absorption, distribution, metabolism, excretion, and toxicity (ADMET) end points and updates the models regularly. We recently examined version-to-version predictivity for… read more here.
Keywords: training set; activity cliffs; version; prediction ... See more keywords
New molecules in plant defence against pathogens.
Sign Up to like & getrecommendations! Published in 2022 at "Essays in biochemistry"
DOI: 10.1042/ebc20210076
Abstract: Plants host a multipart immune signalling network to ward off pathogens. Pathogen attack upon plant tissues can often lead to an amplified state of (induced) defence against subsequent infections in distal tissues; this is known… read more here.
Keywords: plant defence; molecules plant; defence pathogens; defence ... See more keywords
New molecules for atopic dermatitis treatment beyond biological therapy
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000910
Abstract: Purpose of review This review aims to provide a summary of current knowledge on new topical and oral non-biological therapies recently approved for Atopic Dermatitis (AD) treatment. Recent findings The immense research carried out in… read more here.
Keywords: jak inhibitors; dermatitis treatment; treatment; atopic dermatitis ... See more keywords
New Molecules of Diterpene Origin with Inhibitory Properties toward α-Glucosidase
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113535
Abstract: The incidence of diabetes mellitus (DM), one of the most common chronic metabolic disorders, has increased dramatically over the past decade and has resulted in higher rates of morbidity and mortality worldwide. The enzyme, α-Glucosidase… read more here.
Keywords: diterpene origin; inhibitory; quinopimaric acid; molecules diterpene ... See more keywords
New Molecules in Type 2 Diabetes: Advancements, Challenges and Future Directions
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25116218
Abstract: Although good glycemic control in patients with type 2 diabetes (T2D) can prevent cardiovascular complications, many diabetic patients still have poor optimal control. A new class of antidiabetic drugs (e.g., glucagon-like peptide-1-GLP-1 receptor agonists, sodium-glucose… read more here.
Keywords: advancements challenges; new molecules; challenges future; type diabetes ... See more keywords