Indazolylketones as new multitarget cannabinoid drugs.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.030
Abstract: Multitarget cannabinoids could be a promising therapeutic strategic to fight against Alzheimer's disease. In this sense, our group has developed a new family of indazolylketones with multitarget profile including cannabinoids, cholinesterase and BACE-1 activity. A… read more here.
Keywords: new multitarget; multitarget; chemistry; indazolylketones new ... See more keywords
Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.06.073
Abstract: Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin skeleton and an organoselenium motif. Three families were obtained: isoselenocyanate, selenocarbamates and selenoureas. The main purpose of these… read more here.
Keywords: selenocoumarins new; new multitarget; coumarin; silico calculations ... See more keywords
FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00315
Abstract: The discovery of extended catalytic versatilities is of great importance in both the chemistry and biotechnology fields. Fatty acid amide hydrolase (FAAH) belongs to the amidase signature superfamily and is a major endocannabinoid inactivating enzyme… read more here.
Keywords: new multitarget; cleavage; bond; faah catalyzed ... See more keywords