New 1,2,4-oxadiazole/pyrrolidine hybrids as topoisomerase IV and DNA gyrase inhibitors with promising antibacterial activity.
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DOI: 10.1002/ardp.202100516
Abstract: A series of hybridized pyrrolidine compounds with a 1,2,4-oxadiazole moiety were synthesized to develop effective molecules against the enzymes DNA gyrase and topoisomerase IV (Topo IV). Compounds 8-20 were developed based on a previously disclosed… read more here.
Keywords: new oxadiazole; gyrase; activity; topoisomerase ... See more keywords
New 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids as potent antiproliferative agents
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DOI: 10.1002/ardp.202200357
Abstract: A series of new 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids 9a–o and 10a–k were designed and synthesized as potential antiproliferative agents. Hybrids 9a–o exhibited remarkable antiproliferative activities on different NCI‐60 cell lines in a single‐dose assay. The antiproliferative activities… read more here.
Keywords: chalcone benzimidazole; antiproliferative agents; new oxadiazole; benzimidazole hybrids ... See more keywords
Synthesis of new 1,3,4-oxadiazole and benzothiazolylthioether derivatives of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-one as potential antimycobacterial agents
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DOI: 10.1007/s00044-019-02420-7
Abstract: A new series of 4-[(substituted benzylidene)-3-[(5-(pyridine-4-yl)-1,3,4-oxadiazole-2-ylthio)-methyl]isoxazol-5(4H)-one (6a–g) and 4-(substituted benzylidene)-3-((benzo[d]thiazol-2-ylthio)methyl)isoxazol-5(4H)-one (8a–g) was synthesized. All the synthesized compounds were screened for antitubercular activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis BCG (ATCC 35743) and… read more here.
Keywords: new oxadiazole; synthesis new; isoxazol one; oxadiazole benzothiazolylthioether ... See more keywords
Preparation of New Oxadiazole Acyclic Nucleoside and Thioglycoside Analogs Containing Chromene Moiety with Antimicrobial Evaluation
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DOI: 10.37358/rc.17.10.5861
Abstract: New sugar hydrazones linked to chroman ring system and their derived oxadiazole acyclic nucleoside analogs were synthesized from the substituted ethyl ester oxime derivative. The 2-sustituted 1,3,4-oxadiazole5-thione prepared from acid hydrazide was glycosylated to afford… read more here.
Keywords: new oxadiazole; thioglycoside analogs; preparation new; oxadiazole acyclic ... See more keywords