A Robust and Sensitive New Peak Detection and Identification Method for Mass Spectrometry-Based Differential Analysis in Biologics Characterization.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c04913
Abstract: New peak detection (NPD) is a significant component of the multiattribute method (MAM) for MS use to facilitate the detection of quality attributes exhibiting abnormal ratio changes, vanishing attributes, or newly emerging attributes. However, challenges… read more here.
Keywords: detection; method; peak detection; differential analysis ... See more keywords
Using New Peak Detection to Solve Sequence Variants Analysis Challenges in Bioprocess Development.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.2c00292
Abstract: Recombinant therapeutic proteins have become the major class of drugs to treat various human diseases in recent years. Low levels of protein sequence variants (SVs) have been reported to be present in recombinant therapeutic proteins.… read more here.
Keywords: new peak; therapeutic proteins; development; using new ... See more keywords
A Robust Purity Method for Biotherapeutics Using New Peak Detection in an LC-MS-Based Multi-Attribute Method.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.2c00355
Abstract: New peak detection (NPD), as part of the LC-MS-based multi-attribute method (MAM), allows for sensitive and unbiased detection of new or changing site-specific attributes between a sample and reference that is not possible with conventional… read more here.
Keywords: new peak; peak detection; based multi; detection ... See more keywords
A New Peak-Shaving Model Based on Mixed Integer Linear Programming with Variable Peak-Shaving Order
Sign Up to like & getrecommendations! Published in 2021 at "Energies"
DOI: 10.3390/en14040887
Abstract: Peak-shaving is a very efficient and practical strategy for a day-ahead hydropower scheduling in power systems, usually aiming to appropriately schedule hourly (or in less time interval) power generations of individual plants so as to… read more here.
Keywords: shaving order; peak shaving; model; peak ... See more keywords