A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆☆☆
Sign Up to like & getrecommendations! Published in 2020 at "Medical Hypotheses"
DOI: 10.1016/j.mehy.2020.109876
Abstract: Abstract The new zoonotic coronavirus (SARS-CoV-2) responsible for coronavirus disease (COVID-19) is a new strain of coronavirus not previously seen in humans and which appears to come from bat species. It originated in Wuhan, Hubei… read more here.
Keywords: approach based; pharmacological approach; new pharmacological; based remdesivir ... See more keywords
Enkephalinases as a new pharmacological target in the treatment of gastrointestinal tract disorders
Sign Up to like & getrecommendations! Published in 2020 at "Postepy biochemii"
DOI: 10.18388/pb.2020_344
Abstract: Enkephalinases, which belong to the family of zinc metalloproteases play a crucial role in modulation of the endogenous opioid system (EOS) activity. Enkephalinase inhibitors (EI) allow obtaining therapeutic concentrations of selected endogenous peptides. One of… read more here.
Keywords: treatment gastrointestinal; treatment; new pharmacological; enkephalinases new ... See more keywords
New Pharmacological Strategies for the Treatment of Non-Infectious Uveitis. A Minireview
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00655
Abstract: Non-infectious uveitis (NIU) is a group of disorders characterized by intraocular inflammation at different levels of the eye. NIU is a leading cause of irreversible blindness in working-age population in the developed world. The goal… read more here.
Keywords: infectious uveitis; treatment; new pharmacological; pharmacological strategies ... See more keywords
New Pharmacological Approaches for Rare Diseases
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087275
Abstract: The expression "rare disease" describes a group of diseases whose individual prevalence is low (between 3.9 and 6.6 in 10,000 subjects depending on the country) but which in total affect up to the 3-6% of… read more here.
Keywords: new pharmacological; rare diseases; approaches rare; pharmacological approaches ... See more keywords
New pharmacological findings linked to biphenyl DHPMs, kinesin Eg5 ligands: anticancer and antioxidant effects.
Sign Up to like & getrecommendations! Published in 2020 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2019-0256
Abstract: Background: Dihydropyrimidin-2-thiones (DHPMs) are a class of heterocyclic compound which have been intensively investigated mainly due to their anticancer activity as kinesin Eg5 inhibitors. Materials & methods: A library of N1 aryl substituted DHPMs were… read more here.
Keywords: kinesin eg5; cell; new pharmacological; dhpms ... See more keywords