Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels.
Sign Up to like & getrecommendations! Published in 2023 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0428
Abstract: Molecular modification of compounds remains important strategy towards the discovery of new drugs. In this sense, this study presents a new pyrazole derivative 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole (LQFM039) and evaluated the anti-inflammatory, analgesic, and vasorelaxant effects of this compound as well the mechanisms of… read more here.
Keywords: vasorelaxant; new pyrazole; pathway calcium; anti inflammatory ... See more keywords
In Vivo and In Vitro Evaluation of Some New Pyrazole Derivatives in Comparison with Celecoxib
Sign Up to like & getrecommendations! Published in 2023 at "Current Organic Synthesis"
DOI: 10.2174/1570179420666230525105437
Abstract: In the present work, a series of 3-indolyldihydropyrimidine thione containing pyrazole, thiadiazole, and/or benzothiazole were prepared in the form of sulfonamide and sulfohydrazide derivatives in either conventional conditions or under microwave irradiation and evaluated as… read more here.
Keywords: evaluation new; new pyrazole; pyrazole derivatives; vivo vitro ... See more keywords