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Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128850
Abstract: Abstract In this study, the synthesis novel of seven new pyrazolo [5,1-c][1,2,4]triazin derivative disperse dyestuffs was reported. First, 2-arylhydrazone-3-ketiminobutyronitriles were synthesized and reacted with hydrazine hydrate to afford 5-amino-4-arylazo-3-methyl-1H-pyrazoles. The 5-amino-4-arylazo-3-methyl-1H-pyrazoles were diazotised and coupled…
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Keywords:
pyrazolo triazine;
new pyrazolo;
synthesis new;
study synthesis ... See more keywords
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Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2112575
Abstract: Abstract New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds…
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Keywords:
new pyrazolo;
egfrwt egfrt790m;
pyrazolo pyrimidine;
compound 12b ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25010221
Abstract: A series of new pyrazolo[4,3-e][1,2,4]triazine acyclonucleosides 2–5 and 8 were prepared and evaluated for their anticancer activity against human cancer cell lines (MCF-7, K-562) and CDK2/E, as well as Abl protein kinases inhibitors. Lipophilicity of…
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Keywords:
triazine acyclonucleosides;
activity;
pyrazolo triazine;
new pyrazolo ... See more keywords