New pyrrole derivatives as DNA gyrase and 14α-demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22080
Abstract: An efficient one-pot reaction utilizing readily available chemical reagents was used to prepare novel 2-amino-1,5-diaryl-1H-pyrrole-3-carbonitrile derivatives and the structures of these compounds were validated by spectroscopic data and elemental analyses. All the synthetic compounds were… read more here.
Keywords: demethylase; dna gyrase; ic50; gyrase demethylase ... See more keywords
A New Pyrrole Compound from Monascus ruber
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DOI: 10.1007/s10600-019-02903-4
Abstract: Phytochemical investigation of the fungus Monascus ruber led to the isolation of one new alkaloid derivative, namely ruberpyrrole (1). The structures were established by extensive spectroscopic characterization and the reported data. read more here.
Keywords: compound monascus; new pyrrole; chemistry; monascus ... See more keywords
Synthesis, spectroscopic analysis and theoretical study of new pyrrole-isoxazoline derivatives
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DOI: 10.1016/j.molstruc.2016.09.042
Abstract: Abstract In the present work, we have efficiently synthesized the pyrrole-isoxazoline derivatives ( 4a-d ) by cyclization of substituted 4-chalconylpyrrole ( 3a-d ) with hydroxylamine hydrochloride. The reactivity of substituted 4-chalconylpyrrole ( 3a-d ), towards… read more here.
Keywords: pyrrole isoxazoline; new pyrrole; isoxazoline; analysis ... See more keywords
A new pyrrole alkaloid from the mycelium of Inonotus obliquus
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DOI: 10.3184/174751917x14967701766941
Abstract: Inotopyrrole B, a new pyrrole alkaloid, was isolated from the mycelium of Inonotus obliquus together with two known ones, inotopyrrole and 5-(hydroxymethyl)-1H-pyrrole-2-carboxaldehyde. The structure of the new compound was established via detailed analyses of the… read more here.
Keywords: inonotus obliquus; new pyrrole; mycelium inonotus; pyrrole alkaloid ... See more keywords
A Series of New Pyrrole Alkaloids with ALR2 Inhibitory Activities from the Sponge Stylissa massa
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DOI: 10.3390/md20070454
Abstract: Twelve new and four known alkaloids including five different structural scaffolds were isolated from the sponge Stylissa massa collected in the South China Sea. Compound 1 is the first identified precursor metabolite of the classic… read more here.
Keywords: alr2 inhibitory; sponge stylissa; series new; stylissa massa ... See more keywords