Two new pyrrolo-2-aminoimidazoles from a Myanmarese marine sponge, Clathria prolifera
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DOI: 10.1007/s11418-018-1205-y
Abstract: Marine organisms such as marine sponges and soft corals are valuable sources of pharmacologically active secondary metabolites. In our ongoing research on the discovery of new secondary metabolites from marine organisms, two new pyrrolo-2-aminoimidazoles, clathriroles… read more here.
Keywords: sponge; two new; pyrrolo aminoimidazoles; sponge clathria ... See more keywords
Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.09.001
Abstract: Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in cancer angiogenesis. In the current study, a series of novel pyrrolo[2,3-d]pyrimidine based-compounds was designed and synthesized as VEGFR-2 inhibitors, in accordance to the structure… read more here.
Keywords: kinase inhibitors; pyrrolo pyrimidines; identification new; kinase ... See more keywords